Results 21 to 30 of about 3,908,577 (301)

Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint Inhibitors

Biology, 2023
Simple Summary The tumor immune escape mechanisms are key factors in cancer progression and metastasis. They are an undeniable hurdle for successful cancer treatment in patients.
S. Dutta, Anirban Ganguly, K. Chatterjee, Sheila Spada, S. Mukherjee   +4 more
semanticscholar   +1 more source

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

Molecular Cancer, 2023
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression
P. Knopf, D. Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, V. Bucher, M. Poxleitner, Bredi Tako, D. Sonanini, B. Krishnamachary, S. Sinharay, B. Fehrenbacher, I. González-Menéndez, Felix Reckmann, D. Bomze, L. Flatz, Daniela Kramer, M. Schaller, S. Forchhammer, Z. Bhujwalla, Leticia Quintanilla-Martínez, K. Schulze-Osthoff, M. Pagel, M. Fransen, M. Röcken, André F. Martins, Bernd J. Pichler, K. Ghoreschi, M. Kneilling   +28 more
semanticscholar   +1 more source

The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort

Journal of Translational Medicine, 2019
Background The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunotherapy in cancer patients treated with
Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si, Rebecca Halpin, Todd Creasy, Ronald Herbst, Xing Ren, Pascale Morel, Alessandra Cesano, François Goldwasser, Karen Leroy   +23 more
doaj   +1 more source

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy

Molecular Cancer, 2023
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in failure of normal hematopoiesis and life-threating cytopenia.
Tatjana Sauerer, G. F. Velazquez, Christoph Schmid   +2 more
semanticscholar   +1 more source

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Frontiers in Oncology, 2018
Tumors are formed by aggregates of cells of various origins including malignant, stromal and immune cells. The number of therapies targeting the microenvironment is increasing as the tumor microenvironment is more and more recognized as playing an ...
Florent Petitprez, Florent Petitprez, Florent Petitprez, Florent Petitprez, Cheng-Ming Sun, Cheng-Ming Sun, Cheng-Ming Sun, Laetitia Lacroix, Laetitia Lacroix, Laetitia Lacroix, Catherine Sautès-Fridman, Catherine Sautès-Fridman, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman, Wolf H. Fridman, Wolf H. Fridman   +16 more
doaj   +1 more source

Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma

Experimental Hematology & Oncology, 2023
Background Hypoxia is a hallmark of cancer, and is closely intertwined with tumor immune evasion. Circular RNAs (circRNAs) have been implicated in tumor response to immune checkpoint blockades.
Zhi-Qiang Chen, X. Zuo, Jiong Cai, Yao-Yao Zhang, Guo-Yong Han, Long Zhang, Wen-zhou Ding, Jin-Dao Wu, Xue-Hao Wang   +8 more
semanticscholar   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Weber, R., Furrer, H., Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Herrmann, S., James, I., Weber, R., Battegay, M., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Freitas, E., Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Telenti, A., Lucas, M., Freitas, Elizabeth, H. Furrer, Cheng, W., Jeffrey, G., Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, Pfafferott, K., S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., Chapman, R., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Naidoo, K., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, Park, L. P., W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Rauch, A., Mallal, S.A., Gaudieri, S., Mallal, S. A., James, I., Gaudieri, Silvana   +70 more
core   +1 more source

Tertiary Lymphoid Structures: An Anti-tumor School for Adaptive Immune Cells and an Antibody Factory to Fight Cancer?

Frontiers in Immunology, 2017
Tertiary lymphoid structures (TLS) present in human solid tumors are essential for the shaping of a favorable immune micro-environment to control tumor development in most cases.
Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +5 more
doaj   +1 more source

Cancer immune escape: the role of antigen presentation machinery

Journal of Cancer Research and Clinical Oncology, 2023
The mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system.
Anoop Kallingal, Mateusz Olszewski, N. Maciejewska, W. Brankiewicz, M. Bagiński   +4 more
semanticscholar   +1 more source

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Frontiers in Immunology, 2017
The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of ...
Myriam Lawand, Myriam Lawand, Myriam Lawand, Julie Déchanet-Merville, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source