Results 1 to 10 of about 2,659,885 (164)

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Journal of Hematology & Oncology, 2022
Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity.
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam   +6 more
doaj   +2 more sources

A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations

Frontiers in Immunology, 2022
The infective SARS-CoV-2 is more prone to immune escape. Presently, the significant variants of SARS-CoV-2 are emerging in due course of time with substantial mutations, having the immune escape property.
Chiranjib Chakraborty, Ashish Ranjan Sharma, Manojit Bhattacharya, Sang-Soo Lee   +3 more
doaj   +2 more sources

Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

Immunity
As the most frequent genetic alteration in cancer, more than half of human cancers have p53 mutations that cause transcriptional inactivation. However, how p53 modulates the immune landscape to create a niche for immune escape remains elusive.
Yiqing Shen, Zhigang Nian
exaly   +2 more sources

The Architecture of Immune Escape in Neuroblastoma: Plasticity, Silence and Escape Engineer Immune Blindness [PDF]

Cells
Neuroblastoma (NB), the most common extracranial solid tumor of childhood, exemplifies one of the most formidable paradigms of tumor immune evasion (TIME) in pediatric oncology.
Poorvi Subramanian, Loganayaki Periyasamy, Sreenidhi Mohanvelu, Sheeja Aravindan, Natarajan Aravindan   +4 more
doaj   +2 more sources

Tumor immune escape: extracellular vesicles roles and therapeutics application

Cell Communication and Signaling
Background Immune escape, a process by which tumor cells evade immune surveillance, remains a challenge for cancer therapy. Tumor cells produce extracellular vesicles (EVs) that participate in immune escape by transferring bioactive molecules between ...
Mahdi Ahmadi, Reza Abbasi, Jafar Rezaie
doaj   +2 more sources

Neutrophil extracellular traps promote immune escape in hepatocellular carcinoma by up-regulating CD73 through Notch2

Cancer Letters
Immune escape is the main reason that immunotherapy is ineffective in hepatocellular carcinoma (HCC). Here, this study illustrates a pathway mediated by neutrophil extracellular traps (NETs) that can promote immune escape of HCC.
Sheng Tai, Congyi Zhang
exaly   +2 more sources

SARS-CoV-2 variants, spike mutations and immune escape

Nature Reviews Microbiology, 2021
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties and may alter ...
William T. Harvey, A. Carabelli, B. Jackson, Ravindra K. Gupta, E. Thomson, E. Harrison, C. Ludden, R. Reeve, A. Rambaut, S. Peacock, D. Robertson   +10 more
semanticscholar   +1 more source

Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients

Frontiers in Immunology, 2021
The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers. In non-small cell lung cancer (NSCLC), we have previously showed that a high density of B cells within TLS (TLS-B
Claire Germain, Claire Germain, Claire Germain, Claire Germain, Claire Germain, Priyanka Devi-Marulkar, Priyanka Devi-Marulkar, Priyanka Devi-Marulkar, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Jérôme Biton, Jérôme Biton, Jérôme Biton, Hélène Kaplon, Hélène Kaplon, Hélène Kaplon, Laïla Letaïef, Laïla Letaïef, Laïla Letaïef, Laïla Letaïef, Laïla Letaïef, Jérémy Goc, Jérémy Goc, Jérémy Goc, Agathe Seguin-Givelet, Agathe Seguin-Givelet, Agathe Seguin-Givelet, Dominique Gossot, Dominique Gossot, Nicolas Girard, Pierre Validire, Pierre Validire, Marine Lefèvre, Marine Lefèvre, Marine Lefèvre, Diane Damotte, Diane Damotte, Diane Damotte, Diane Damotte, Marco Alifano, Marco Alifano, Marco Alifano, Marco Alifano, François M. Lemoine, François M. Lemoine, Keith E. Steele, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Scott A. Hammond, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +57 more
doaj   +1 more source

SARS-CoV-2 variant biology: immune escape, transmission and fitness

Nature Reviews Microbiology, 2023
In late 2020, after circulating for almost a year in the human population, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its adaptation to humans. These highly mutated forms of SARS-CoV-2 had enhanced rates
A. Carabelli, T. Peacock, Lucy G. Thorne, William T. Harvey, J. Hughes, T. D. de Silva, S. Peacock, W. Barclay, G. Towers, David L. Robertson   +9 more
semanticscholar   +1 more source

Tumor Immune Escape and Treatment [PDF]

BIO Web of Conferences, 2022
Tumor immune escape is one of the ten characteristics of tumor occurrence and development. Immunotherapy targeting immune escape has achieved remarkable success in recent years.
Wang Yuncong
doaj   +1 more source