Results 31 to 40 of about 1,542,000 (267)

Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer

Molecular Cancer
Background Breast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While early detection and targeted therapies have improved overall life expectancy, TNBC remains resistant to current treatments.
Claudia Cifuentes, Clara L. Oeste, Isabel Fernández-Pisonero, Alejandro M. Hortal, Carmen García-Macías, Jeanne Hochart, Regina Rubira, Lydia Horndler, Carlos Horndler, Xosé R. Bustelo, Balbino Alarcón   +10 more
doaj   +1 more source

Effect of Lycium barbarum Leaves Polysaccharides on Biological Metabolism, Antioxidant Capacity, Immune Function and Intestinal Microbiota in Mice

Shipin gongye ke-ji, 2023
Objective: To investigate the effects of normal group without gavage of LBP and various doses of Lycium barbarum leaves polysaccharides (LBP) on mouse metabolism, antioxidant, immune function, and intestinal microorganisms, C57BL/6 female mice were ...
Min BAI, Ying ZHANG, Quanji LI, Jin JI, Yating JIN, Qi WANG, Jiaqing ZHAO   +6 more
doaj   +1 more source

Melatonin, Immune Function and Cancer [PDF]

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2011
Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost
Srinivasan, Venkatramanujam, Pandi Perumal, Seithikurippu R., Brzezinsk, Amnon, Bhatnagar, Kunwar P., Cardinali, Daniel Pedro   +4 more
openaire   +4 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior

Journal of Hematology & Oncology
Background Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies.
Claudia Cifuentes, Lydia Horndler, Pilar Grosso, Clara L Oeste, Alejandro M. Hortal, Jennifer Castillo, Isabel Fernández-Pisonero, Alberto Paradela, Xosé Bustelo, Balbino Alarcón   +9 more
doaj   +1 more source

Expression of Gallus Epidermal Growth Factor (gEGF) with Food-Grade Lactococcus lactis Expression System and Its Biological Effects on Broiler Chickens

Biomolecules, 2021
As a multifunctional polypeptide, epidermal growth factor (EGF) increases growth performance or enhances resistance to diseases in commercial broilers under adverse conditions.
Yu Zhou, Pinpin Chen, Shuai Shi, Xiaowen Li, Deshi Shi, Zutao Zhou, Zili Li, Yuncai Xiao   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Influence of vitamin D supplementation on immune function of healthy aging people: A pilot randomized controlled trial

Frontiers in Nutrition, 2022
ObjectivesThis study aims to investigate the influence of vitamin D supplementation on immune function of healthy older adults.Materials and methodsDesigned as a randomized controlled trial, 21 participants (55–85 years) completed the study during May ...
Honglin Dong, Honglin Dong, Viktorija Asmolovaite, Sebastien Farnaud, Derek Renshaw   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support [PDF]

Journal of Medical Biochemistry
Background: This study aimed to evaluate the effects of nutritional support combined with stratified nursing under delirium risk assessment on immune function and postoperative delirium in elderly hip fracture patients.
Jin Fangqin, Zhang Qin, Weng Jiangping, Pan Xuting, Dong Qinyan, Zhao Yuping   +5 more
doaj   +1 more source