Results 111 to 120 of about 2,585,977 (417)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer [PDF]

, 2008
The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited.
A Ciucci, A Lannigan, A-M McNicol, AHS Lee, AHS Lee, AM Al Murri, AM Al Murri, AM Al Murri, AM McNicol, B Uzzan, C Badoual, C O'Sullivan, C Wilson, CD Griffith, CG Lis, D C McMillan, DC McMillan, DC McMillan, DC McMillan, EJ Bromwich, EY Lin, G Zhang, H Trihia, HM Ogmundsdottir, HO Wintzer, I Laursen, J Bell, J C Doughty, J Galon, J Vakkila, JA Anderson, JA Soreide, JL Yu, K Canna, KV Albuquerque, LM Coussens, LM Forrest, M Hilmy, M Retsky, M Toi, MC Haffner, MP Margarson, N Jonjic, P Goldwasser, P Reizenstein, PA McArdle, RD Leek, S Hansen, S Hansen, S Tsutsui, S Vgenopoulou, SM Pupa, SM Veronese, T Scholzen, TH Stewart, V Carstairs, Y Zhou   +56 more
core   +2 more sources

Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Increasing evidence has demonstrated the functional relevance of long non-coding RNAs (lncRNAs) to immunity regulation and the tumor microenvironment in non-small cell lung cancer (NSCLC).
Jie Sun, Zicheng Zhang, S. Bao, Congcong Yan, P. Hou, N. Wu, Jianzhong Su, Liangde Xu, Meng Zhou   +8 more
semanticscholar   +1 more source

Role of Necroptosis and Immune Infiltration in Human Stanford Type A Aortic Dissection: Novel Insights from Bioinformatics Analyses

Oxidative Medicine and Cellular Longevity, 2022
Background. Stanford type A aortic dissection (TAAD) is one of the most life‐threatening cardiovascular emergencies with high mortality and morbidity, and necroptosis is a newly identified type of programmed cell death and contributes to the pathogenesis
Fuqiang Liu, Tao Wei, Lin Liu, Fangxia Hou, Cuixiang Xu, Hua Guo, Wei Zhang, Meijuan Ma, Yulian Zhang, Qi Yu, Junkui Wang   +10 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoprotein expression and immunopathology. [PDF]

, 2004
Differences in disease outcome between the highly neurovirulent MHV-JHM and mildly neurovirulent MHV-A59 have been attributed to variations within the spike (S) glycoprotein.
An, Askovic, Basler, Baudoux, Buchmeier, Castro, Drescher, Fazakerley, Fleming, Fleming, Haring, Haring, Ito, Jeffrey Meisner, Julia D. Rempel, Kubo, Lane, Lavi, Luo, Marten, Michael J. Buchmeier, Parker, Perlman, Phillips, Rempel, Schijns, Shannon J. Murray, Song, Stalder, Stohlman, Taguchi, Talbot, Talbot, Wege, Wu, Xiong, Yee, Zhang   +37 more
core   +1 more source

Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer

Immunological Reviews, 2021
The tumor microenvironment (TME) has been identified as one of the driving factors of tumor progression and invasion. Within this microenvironment, cancer‐associated fibroblasts (CAF) have multiple tumor‐promoting functions and play key roles in drug ...
R. Mhaidly, F. Mechta-Grigoriou
semanticscholar   +1 more source

Tumor infiltrating immune cells in gliomas and meningiomas

Brain, Behavior, and Immunity, 2016
Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, with relevant effects on patient behavior.
Domingues, Patricia H., González-Tablas, María, Otero, Álvaro, Pascual-Argente, Daniel, Miranda, David, Ruiz-Martin, Laura, Sousa, Pablo, Ciudad, Juana, Gonçalves, Jesús, Lopes, Maria Celeste, Orfao, Alberto, Tabernero, María D.   +11 more
openaire   +4 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Prediction of a T-cell/MHC-I-based immune profile for colorectal liver metastases from CT images using ensemble learning [PDF]

arXiv, 2023
Colorectal cancer liver metastases (CLM) are the most common type of distant metastases originating from the abdomen and are characterized by a high recurrence rate after curative resection. It has been previously reported that CLM presenting a low cluster of differentiation 3 (CD3) positive T-cell infiltration density concurrent with a high major ...
arxiv