Results 101 to 110 of about 1,838,932 (310)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

DNA alteration‐based classification of uveal melanoma gives better prognostic stratification than immune infiltration, which has a neutral effect in high‐risk group

Cancer Medicine, 2019
Background In uveal melanomas, immune infiltration is a marker of poor prognosis. This work intended to decipher the biological characteristics of intra‐tumor immune population, compare it to other established biomarkers and to patients' outcome. Methods
Deepti Narasimhaiah, Catherine Legrand, Diane Damotte, Romain Remark, Marco Munda, Patrick De Potter, Pierre G. Coulie, Miikka Vikkula, Catherine Godfraind   +8 more
doaj   +1 more source

The landscape of immune infiltration in HCC.

, 2020
(A) The different immune infiltration of 22 tumor-infiltrating immune cells (TIICs) between HCC and paired normal tissue; (B) The difference of TIICs proportions and CIBERSORT p-value; (C) The association between immune cytolytic activity and CIBERSORT p-
Min Jiao (2221057), Jia Hou (522373), SiZhe Yu (8661537), Yu Wang (12152), WenYuan Li (8661540), Hui Guo (110581), Xiao Wang (19312), LiLi Jiang (5651716), WenJuan Wang (5516429), LuoChengLing Xiang (8661543), DeLi Tan (8661546), Francois X. Claret (8661549)   +11 more
core   +1 more source

The risk scores of immunological infiltration and immune functions in the subgroups.

, 2023
(A) The ssGSEA scores of immunological infiltration. (B) The ssGSEA scores of immune functions.
Yue-Ling Peng (6114215), Ya-Fang Dong (16748007), Rong-Shan Li (157036), Li-Li Guo (6166310), Mu-Ye Li (16748010), Hui Liao (452190)   +5 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Correlation between classic UCEC associated genic SNV and immune infiltration pattern.

, 2023
Correlation between classic UCEC associated genic SNV and immune infiltration pattern.
Zehua Wang (556154), Wenwen Wang (534041), Guoqing Li (23674), Xiaoqi He (11609968), Jing Cai (112307), Minggang Peng (6415361), Qiang Yang (135832), Si Sun (771598), Man Xiao (556153)   +8 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study

OncoImmunology, 2020
Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates in OC because of its heterogeneity.
Yue Gao, Lingxi Chen, Guangyao Cai, Xiaoming Xiong, Yuan Wu, Ding Ma, Shuai Cheng Li, Qinglei Gao   +7 more
doaj   +1 more source

Additional file 2 of Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer

, 2022
Additional file 2: Figure S2. The correlation between the CNV or mutation of hub genes and the immune infiltration. (A) CDKN2A. (B) CMTM8.
Shengxiong Chen (12425017), Ning Kang (327210), Ting Liu (45625), Xiaoli Xie (4496059), Yijun Wang (321141), Huiqing Jiang (10820429), Xue Zhou (68629), Ran Qi (4630798)   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source