Results 81 to 90 of about 1,707,239 (310)

Quantitative Analysis of Immune Infiltrates in Primary Melanoma [PDF]

Cancer Immunology Research, 2018
Abstract Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application.
Gartrell, Robyn D., Marks, Douglas K., Hart, Thomas D., Li, Gen, Davari, Danielle R., Wu, Alan, Blake, Zoë, Lu, Yan, Askin. Kayleigh N., Monod, Anthea, Esancy, Camden L., Stack, Edward C., Jia, Dan Tong, Armenta, Paul M., Fu, Yichun, Izaki, Daisuke, Taback, Bret, Rabadan, Raul, Kaufman, Howard L., Drake, Charles G., Horst, Basil, Saenger, Yvonne M.   +21 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Profiling Tumor Infiltrating Immune Cells with CIBERSORT [PDF]

, 2018
Tumor infiltrating leukocytes (TILs) are an integral component of the tumor microenvironment and have been found to correlate with prognosis and response to therapy. Methods to enumerate immune subsets such as immunohistochemistry or flow cytometry suffer from limitations in phenotypic markers and can be challenging to practically implement and ...
Binbin, Chen, Michael S, Khodadoust, Chih Long, Liu, Aaron M, Newman, Ash A, Alizadeh   +4 more
openaire   +2 more sources

SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target

BMC Cancer, 2021
Background The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes.
Shaokun Wang, Li Pang, Zuolong Liu, Xiangwei Meng   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tumor-Infiltrating Immune Cells in Colorectal Cancer [PDF]

Neoplasia
Colorectal cancer encompasses a heterogeneous group of malignancies that differ in pathophysiological mechanisms, immune response and infiltration, therapeutic response, and clinical prognosis. Numerous studies have highlighted the clinical relevance of tumor-infiltrating immune cells among different types of colorectal tumors yet vary in cell type ...
Sonia A.M. Ferkel, Elizabeth A. Holman, Raoul S. Sojwal, Samuel J.S. Rubin, Stephan Rogalla   +4 more
openaire   +4 more sources

ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma

Journal of Immunology Research, 2022
Purpose. To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs). Method.
Qiu Sun, Xudong Liu, Qunlong Peng, Lei Hu, Xiaochun Jiang   +4 more
doaj   +1 more source

Infiltration characteristics of furrow irrigation in a heavy-textured soil [PDF]

, 1972
The objective of this thesis is to study the rate and pattern of infiltration of soil water, under the conditions of heavy texture and shallow depth in a tropical furrow- irrigated soil.
Grassi, C.J.
core  

Associations between CDCA2 expression and immune cell infiltration in LGG.

, 2023
(A) The correlation between CDCA2 and immune cell infiltration; (B, C, D) The correlation between CDCA2 and stromalscore, immune score and estimate score; (E) The differential expression of immune cells in the high and low CDCA2 expression groups in LGG;
Wenle Li (1234731), Chengjie Xu (9231483), Zhenzhe Li (7322933), Wensheng Li (309393), Dong Lv (3355730), Huanqiang Liu (17020744), Jieqin Yao (17020738), Boxian Chen (17020741)   +7 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source