Results 71 to 80 of about 1,838,932 (310)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Relationship Between Expressions of SDHx Genes and Immune Cell Infiltration in Pheochromocytoma/Paraganglioma

Xiehe Yixue Zazhi
ObjectiveTo investigate the characteristics and differences of immune cell infiltration between different SDHx gene expression and pheochromocytoma/paraganglioma(PPGL).MethodsRNAseqdata of PPGL were downloaded and organized from The Cancer Genome Atlas ...
WANG Pu, GAO Liming, ZHANG Wenyang, YE Ting, LI Hongyan, GUO Rui   +5 more
doaj   +1 more source

Additional file 1 of Identification of immune infiltration-related genes as prognostic indicators for hepatocellular carcinoma

, 2022
Additional file 1: Table S1.
Ge Guan (4527250), Liqun Wu (3196299), Kunfu Dai (12508202), Jinzhen Cai (849136), Chao Liu (43092)   +4 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Identifying Immune Cell Infiltration and Hub Genes During the Myocardial Remodeling Process After Myocardial Infarction

, 2023
Yuan Tian,1,* Zilin Wang,2,* Feng Liang,3,* Yi Wang1 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People’s Republic of China; 2Department of Radiology, Shanghai ...
Liang F, Tian Y, Wang Y, Wang Z
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.

PLoS ONE
The immune microenvironment is critical in gastric cancer (GC), yet epithelial-specific genes linked to immune infiltration remain poorly defined.
Linen Li, Hao Chen, Feng Zhou, Yanqing Shi   +3 more
doaj   +1 more source

TIMER based Spearman correlational analysis between the expression of real hub genes and CD8+ T immune cell infiltration in COAD.

, 2021
TIMER based Spearman correlational analysis between: (A) CXCL12 expression and CD8+ T immune cell infiltration; (B) CXCL8 expression and CD8+ T immune cells’ infiltration; (C) AGT expression and CD8+ T immune cells’ infiltration; (D) GNB1 expression and ...
Shufang Liang (781312), Muhammad Usman (1504405), Samina Ejaz (11378800), Yasir Hameed (8939681)   +3 more
core   +1 more source

Profiling Tumor Infiltrating Immune Cells with CIBERSORT [PDF]

, 2018
Tumor infiltrating leukocytes (TILs) are an integral component of the tumor microenvironment and have been found to correlate with prognosis and response to therapy. Methods to enumerate immune subsets such as immunohistochemistry or flow cytometry suffer from limitations in phenotypic markers and can be challenging to practically implement and ...
Binbin, Chen, Michael S, Khodadoust, Chih Long, Liu, Aaron M, Newman, Ash A, Alizadeh   +4 more
openaire   +2 more sources

Quantitative Analysis of Immune Infiltrates in Primary Melanoma [PDF]

Cancer Immunology Research, 2018
Abstract Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application.
Gartrell, Robyn D., Marks, Douglas K., Hart, Thomas D., Li, Gen, Davari, Danielle R., Wu, Alan, Blake, Zoë, Lu, Yan, Askin. Kayleigh N., Monod, Anthea, Esancy, Camden L., Stack, Edward C., Jia, Dan Tong, Armenta, Paul M., Fu, Yichun, Izaki, Daisuke, Taback, Bret, Rabadan, Raul, Kaufman, Howard L., Drake, Charles G., Horst, Basil, Saenger, Yvonne M.   +21 more
openaire   +3 more sources