Results 51 to 60 of about 1,838,932 (310)

Immune infiltration, glioma stratification, and therapeutic implications [PDF]

Translational Cancer Research, 2016
By definition, gliomas are brain tumors emanating from glial precursor cells. Gliomas include glioblastoma (GBM), astrocytoma, oligodendroglioma, and ependymoma. The World Health Organization (WHO) traditionally classifies brain tumors according to their pathological features, with GBM having the highest grade (IV), while lower grades (mostly II, III ...
Manny D, Bacolod, Sarmistha, Talukdar, Luni, Emdad, Swadesh K, Das, Devanand, Sarkar, Xiang-Yang, Wang, Francis, Barany, Paul B, Fisher   +7 more
openaire   +2 more sources

Associations between CDCA2 expression and immune cell infiltration in LGG.

, 2023
(A) The correlation between CDCA2 and immune cell infiltration; (B, C, D) The correlation between CDCA2 and stromalscore, immune score and estimate score; (E) The differential expression of immune cells in the high and low CDCA2 expression groups in LGG;
Wenle Li (1234731), Chengjie Xu (9231483), Zhenzhe Li (7322933), Wensheng Li (309393), Dong Lv (3355730), Huanqiang Liu (17020744), Jieqin Yao (17020738), Boxian Chen (17020741)   +7 more
core   +1 more source

Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients

Frontiers in Oncology, 2021
Reports indicate that the use of anti-programmed cell death-1 (PD-1) and death ligand-1 (PD-L1) monoclonal antibodies for the treatment of patients diagnosed with melanoma has demonstrated promising efficacy.
Gang Li, Xuran Zhu, Chao Liu
doaj   +1 more source

Correlation analysis of SNX16 and PAPOLG expression with immune infiltration.

, 2022
Correlation of SNX16 (A) and PAPOLG (B) expression with the level of immune cell infiltration. (C) Survival curves to analyze the relationship between six types of immune cell infiltration and overall survival of patients with HCC.
Jing Dai (470985), Jinyan Zhang (759953), Shangshang Hu (10915431), Guoqing Guo (11417031), Yu Gao (69071), Li Zhang (8200)   +5 more
core   +1 more source

Characterization of immune infiltration in sarcomatoid hepatocellular carcinoma

Aging, 2021
Sarcomatoid hepatocellular carcinoma (sHCC) is a rare type of liver malignancy. Currently, the tumor immune features of sHCC are poorly understood. We recruited 31 patients with resected sHCC for whom tissue samples and complete clinicopathologic and follow-up data were available.
Luo, Chubin, Xin, Haoyang, Yin, Dan, Zhao, Tongyi, Hu, Zhiqiang, Zhou, Zhengjun, Sun, Rongqi, Yao, Na, Sun, Qiman, Fan, Jia, Huang, Xiaowu, Zhou, Jian, Zhou, Shaolai   +12 more
openaire   +2 more sources

The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied
Yuanyuan Guo, Yuanyuan Guo, Jing Yang, Jing Yang, Kaidi Ren, Kaidi Ren, Xueke Tian, Xueke Tian, Hua Gao, Xin Tian, Xin Tian, Xiaojian Zhang, Xiaojian Zhang, Quancheng Kan, Quancheng Kan   +14 more
doaj   +1 more source

Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model [PDF]

, 2010
Background: Hemorrhagic shock/resuscitation is associated with aberrant neutrophil activation and organ failure. This experimental porcine study was done to evaluate the effects of Fas-directed extracorporeal immune therapy with a leukocyte inhibition ...
Sarah Sadek, Altrichter, Jens, José Bitu-Moreno, Windolf Joachim, Scholz Martin, Ott Annina, Sadek Sarah, Teresa Jeri, Adnana Paunel-Görgülü, Martin Sager, Baltes Jessica, Müller, Wolfram, Sager, Martin, Witte Ingo, Ingo Witte, Jens Altrichter, Martin Scholz, Sager Martin, Sadek, Sarah, Schek, Alberto, Bitu-Moreno José, Windolf, Joachim, Lögters, Tim Tobias, Witte, Ingo, Bitu-Moreno, José, Jeri, Teresa, Altrichter Jens, Paunel-Görgülü Adnana, Jeri Teresa, Joachim Windolf, Alberto Schek, Baltes, Jessica, Wolfram Müller, Annina Ott, Müller Wolfram, Schek Alberto, Scholz, Martin, Jessica Baltes, Ott, Annina, Tim T Lögters, Paunel-Görgülü, Adnana-Nicoleta, Lögters Tim T   +41 more
core   +1 more source

MLK4 mRNA expression level is related to immune cell infiltration.

, 2023
A. ESTIMATE was used to analyze the correlation between MLK4 and immune cell infiltration in cervical cancer B. The correlation between MLK4 and immune program was analyzed by IPS; C. Four different algorithms were used to analyze the correlation between
Li Hong (426614), Fujin Shen (16851498), Yang Li (7082), Meng Gong (5170457), Lei Ming (1807879)   +4 more
core   +1 more source

Stromal score is a promising index in tumor patients’ outcome determination

Heliyon, 2023
Background: Immune status is widely acknowledged as a valuable marker for predicting cancer prognosis and therapy response. However, there has been a limited understanding of the stromal landscape in cancer.
Xiaoxian Xu, Yu Xu, Wangxiong Hu, Wenjie Hong, Yichen Wang, Xiaojing Zhang, Xiaoji Fan, Tingzhang Wang, Hanmei Lou, Yanmei Yang, Jianhua Qian   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source