Results 51 to 60 of about 469,505 (262)

Quantitative Analysis of Immune Infiltrates in Primary Melanoma [PDF]

Cancer Immunology Research, 2018
Abstract Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application.
Gartrell, Robyn D., Marks, Douglas K., Hart, Thomas D., Li, Gen, Davari, Danielle R., Wu, Alan, Blake, Zoë, Lu, Yan, Askin. Kayleigh N., Monod, Anthea, Esancy, Camden L., Stack, Edward C., Jia, Dan Tong, Armenta, Paul M., Fu, Yichun, Izaki, Daisuke, Taback, Bret, Rabadan, Raul, Kaufman, Howard L., Drake, Charles G., Horst, Basil, Saenger, Yvonne M.   +21 more
openaire   +3 more sources

The Landscape of Immune Cells Infiltrating in Prostate Cancer [PDF]

Frontiers in Oncology, 2020
This study was to explore the infiltration pattern of immune cells in the prostate cancer (PCa) microenvironment and evaluate the possibility of specific infiltrating immune cells as potential prognostic biomarkers in PCa.Infiltrating percentage of 22 immune cells were extracted from 27 normalized datasets by CIBERSORT algorithm. Samples with CIBERSORT
Zhicong Wu, Zhicong Wu, Hua Chen, Wenyang Luo, Hanyun Zhang, Guihuan Li, Fangyin Zeng, Fan Deng   +7 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Characterization of immune infiltration in sarcomatoid hepatocellular carcinoma

Aging, 2021
Sarcomatoid hepatocellular carcinoma (sHCC) is a rare type of liver malignancy. Currently, the tumor immune features of sHCC are poorly understood. We recruited 31 patients with resected sHCC for whom tissue samples and complete clinicopathologic and follow-up data were available.
Luo, Chubin, Xin, Haoyang, Yin, Dan, Zhao, Tongyi, Hu, Zhiqiang, Zhou, Zhengjun, Sun, Rongqi, Yao, Na, Sun, Qiman, Fan, Jia, Huang, Xiaowu, Zhou, Jian, Zhou, Shaolai   +12 more
openaire   +2 more sources

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Relationship Between Expressions of SDHx Genes and Immune Cell Infiltration in Pheochromocytoma/Paraganglioma

Xiehe Yixue Zazhi
ObjectiveTo investigate the characteristics and differences of immune cell infiltration between different SDHx gene expression and pheochromocytoma/paraganglioma(PPGL).MethodsRNAseqdata of PPGL were downloaded and organized from The Cancer Genome Atlas ...
WANG Pu, GAO Liming, ZHANG Wenyang, YE Ting, LI Hongyan, GUO Rui   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Immune cell infiltration and immunotherapy in hepatocellular carcinoma

Mathematical Biosciences and Engineering, 2022
<abstract><p>Hepatocellular carcinoma is a highly malignant tumor and patients yield limited benefits from the existing treatments. The application of immune checkpoint inhibitors is promising but the results described in the literature are not favorable.
Yu Jiang, Lijuan Lin, Huiming Lv, He Zhang, Lili Jiang, Fenfen Ma, Qiuyue Wang, Xue Ma, Shengjin Yu   +8 more
openaire   +3 more sources