Results 41 to 50 of about 668,593 (306)
Molecular Therapy: Oncolytics, 2022 Hepatocellular carcinoma (HCC) is highly heterogeneous. Molecular subtyping for guiding immunotherapy is warranted. Previous studies have indicated that enhancer RNAs (eRNAs) are involved in tumor heterogeneity and immune infiltration.
Xiaoyun Bu +6 more
doaj +1 more source
Immune Characteristics in Biliary Atresia Based on Immune Genes and Immune Cell Infiltration
Frontiers in Pediatrics, 2022 BackgroundBiliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis. The pathogenesis of BA is not clear, and it is now generally
Chenyu Yang +7 more
openaire +3 more sources
Frontiers in Oncology, 2019 Background: Invasive ductal carcinoma (IDC) is a clinically and molecularly distinct disease. Tumor microenvironment (TME) immune phenotypes play crucial roles in predicting clinical outcomes and therapeutic efficacy.Method: In this study, we depict the ...
Xuanwen Bao +7 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundThe tumor microenvironment (TME) involves infiltration of multiple immune cell subsets, which could influence the prognosis and clinical characteristics.
Dan Liu, Xue Yang, Xiongzhi Wu
doaj +1 more source
Histopathological image QTL discovery of immune infiltration variants [PDF]
iScience, 2017 AbstractGenotype-to-phenotype association studies typically use macroscopic physiological measurements or molecular readouts as quantitative traits. There are comparatively few suitable quantitative traits available between cell and tissue length scales, a limitation that hinders our ability to identify variants affecting phenotype at many clinically ...
Barry, Joseph D. +5 more
openaire +5 more sources
Frontiers in Immunology, 2023 BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA ...
Xinyue Zhang +3 more
doaj +1 more source
The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]
, 2016 Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L. +6 more
core +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
Distribution of Tumor-Infiltrating Immune Cells in Glioblastoma [PDF]
CNS Oncology, 2018 Evaluation of features related to infiltrating immune cell level in glioblastoma.Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis.CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest ...
Enrique Orrego +13 more
openaire +3 more sources
Identification of testicular cancer immune infiltrates and novel immune cell subtypes
FEBS Open Bio, 2023 Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear.
Zhiguo Zhu +5 more
openaire +3 more sources