Results 21 to 30 of about 668,593 (306)

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. [PDF]

, 2018
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity.
A Gladiator, A Ray, AC Patera, AD Joshi, AK Furuya, AM Owyang, AV Ivanov, AY Wen, BC Xu, C Zhao, CE Andoniou, CO Simon, CR Crowe, CW Lio, D Burdette, EH Kobayashi, GJ Bancroft, GM DeNicola, H Kato, H Kawasaki, HS Zhang, HY Cho, J Bystrom, J Lee, JL Bowen, JM Lee, K Tabeta, KA Daniels, KJ Livak, KL Hokeness, KL Hokeness, KM Hsu, LR Johnson, M Boeckh, M Wagner, MA Stacey, MC Cheeran, MJ Crane, MJ Kesic, MJ Reddehase, MK Arababadi, N Nagai, NM Reddy, P Balanescu, P Ye, Q Ma, R Guabiraba, R Saddawi-Konefka, R Seelige, R Seelige, RK Thimmulappa, RL Wheat, S Jonjic, S Jordan, S Kohyama, S Mamo, S Schaedler, S Sell, SL Deshmane, SL Gaffen, SP Francis, T O’Sullivan, T Starnes, TP Salazar-Mather, V Ramirez-Carrozzi, VA Rathinam, W Hou, W Hou, X Song, X Wang, Y Iwakura, Y Shinkai, Y Yageta, Y Zhang, YL Cheng, Z Huang   +75 more
core   +3 more sources

Immune infiltration and immunophenotyping in atrial fibrillation

Aging, 2023
الرجفان الأذيني هو اضطراب نظم شائع نسبيًا في الممارسة السريرية. على الرغم من إحراز تقدم كبير في علاج الرجفان الأذيني والمضاعفات المرتبطة به، إلا أن الأبحاث حول الوقاية من الرجفان الأذيني متخلفة، ويرجع ذلك أساسًا إلى عدم وجود فهم عميق للتسبب في الرجفان الأذيني.
Yuqing Tian, Shiying Liu, Yanan Zhang, Jiefu Yang, Peiyao Guo, Hongchao Zhang, Yu Xue, Tong Zou   +7 more
openaire   +2 more sources

The immune phenotypes and different immune escape mechanisms in colorectal cancer

Frontiers in Immunology, 2022
The tumor microenvironment (TME) plays a crucial role in tumor progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) and the underlying immune escape mechanism have not been studied sufficiently.
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Qi Lin, Wentao Tang, Wentao Tang, Dexiang Zhu, Dexiang Zhu, Meiling Ji, Meiling Ji, Guodong He, Guodong He, Qingyang Feng, Qingyang Feng, Jianmin Xu, Jianmin Xu   +22 more
doaj   +1 more source

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system.
Azad, Abul, D'Costa, Zenobia, Diana, Angela, Dushek, Omer, Fokas, Emmanouil, Jones, Keaton, Kruger, Philipp, Liu, Stanley, McKenna, W. Gillies, Muschel, Ruth J., Sansom, Owen J., Yin Lim, Su   +11 more
core   +1 more source

Immune infiltration, glioma stratification, and therapeutic implications [PDF]

Translational Cancer Research, 2016
By definition, gliomas are brain tumors emanating from glial precursor cells. Gliomas include glioblastoma (GBM), astrocytoma, oligodendroglioma, and ependymoma. The World Health Organization (WHO) traditionally classifies brain tumors according to their pathological features, with GBM having the highest grade (IV), while lower grades (mostly II, III ...
Manny D, Bacolod, Sarmistha, Talukdar, Luni, Emdad, Swadesh K, Das, Devanand, Sarkar, Xiang-Yang, Wang, Francis, Barany, Paul B, Fisher   +7 more
openaire   +2 more sources

Immune Cell Infiltrate and Prognosis in Gastric Cancer [PDF]

Cancers, 2020
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade.
Niko Kemi, Niko Hiltunen, Juha P. Väyrynen, Vesa-Matti Pohjanen, Olli Helminen, Anna Junttila, Johanna Mrena, Jan Böhm, Heikki Huhta, Joni Leppänen, Tuomo J. Karttunen, Joonas H. Kauppila   +11 more
openaire   +3 more sources

WHSC1/NSD2 regulates immune infiltration in prostate cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2021
BackgroundImmunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because of its limited immune infiltration. Tumor-resident immune cells have been detected in the prostate, but the regulatory mechanisms that govern tumor infiltration are still poorly understood.
Muzamil Y Want, Takemasa Tsuji, Prashant K Singh, James L Thorne, Junko Matsuzaki, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Richard C. Koya, Amit Lugade, Kunle Odunsi, Sebastiano Battaglia   +11 more
openaire   +5 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]

, 2015
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria, Cattarino, Susanna, Collalti, Giulia, Sciarra, Alessandro, Silvestri, Ida   +4 more
core   +6 more sources

Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma

Frontiers in Immunology, 2020
Background: The tumor microenvironment (TME) consists of heterogeneous cell populations, including malignant cells and nonmalignant cells that support tumor proliferation, invasion, and metastasis through extensive cross talk.
Shuguang Zuo, Min Wei, Shiqun Wang, Jie Dong, Jiwu Wei, Jiwu Wei   +5 more
doaj   +1 more source