Results 91 to 100 of about 1,707,239 (310)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma

Journal of Immunology Research, 2022
Osteosarcoma is a kind of primary malignant tumor of bone. In recent years, its therapeutic effect and prognostic survival are dissatisfactory. The tumor immune microenvironment (TIME) reflects immune status of patients, but it is little known in ...
Shunhan Yao, Meiling Deng, Xiaojing Du, Qingfeng Chen, Rongzhi Huang   +4 more
doaj   +1 more source

CIBERSORT algorithm calculates immune infiltration of 22 types of immune cells.

, 2023
CIBERSORT algorithm calculates immune infiltration of 22 types of immune cells.
Yanchi Fu (17583233), Huixue Zhang (614029), Jianjian Wang (288375), Lihua Wang (14548), Yijie He (6882242), Lixia Chen (614030), Qinghua Tian (614031), Xiaotong Kong (6555797), Guanghao Xin (17583227)   +8 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Correlation analysis between PLAUR expression and immune cell infiltration.

, 2022
A. Correlation between high and low PLAUR expression and ImmuneScore; B. Correlation between Grade and ImmuneScore; C. Correlation between Stage and ImmuneScore; D. Correlation between T stage and ImmuneScore; E.
Zengshu Xing (12837293), Zhiwei Wang (120259), Kunxiong Wang (12837290), Xin Gao (14001), Zhenxiang Liu (534118)   +4 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Exploring LTB-mediated T cell differentiation as a prognostic marker in triple-negative breast cancer

Breast Cancer Research
Immune infiltration in triple-negative breast cancer (TNBC) is associated with patient prognosis. However, the precise phenotypic classifications of immune infiltration in TNBC remain unclear, and the key regulatory mechanisms underlying this process ...
Xuekai Wang, Yingxiao Ni, Yang Shi, Xiaofeng Yu, Chenchen Wu, Zhuo Xiang, Wei Lv, Qiang Wang   +7 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Leveraging machine learning models to evaluate immune infiltration in the ovarian cancer microenvironment: a single-cell analysis approach

Discover Oncology
Background The prognosis of ovarian cancer is closely related to the degree of immune cell infiltration within the tumor microenvironment. However, current methods for assessing immune infiltration have certain subjective limitations. This study aimed to
Jie Liu, Baoguo Xia, Bingxin Li, Hui Liang   +3 more
doaj   +1 more source

CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice.

PLoS ONE, 2019
Complex interactions between HSV-1 and infiltrating immune cells play important roles in establishing localized, acute virus replication as well as chronic latent infection. The extent and duration of initial virus replication are the key determinants of
Dhong Hyun Lee, Ujjaldeep Jaggi, Homayon Ghiasi   +2 more
doaj   +1 more source