Results 261 to 270 of about 1,838,932 (310)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Immune Infiltration Landscape in Osteosarcoma: Clinical Implications for Prognosis and Therapy. [PDF]

Cancer Rep (Hoboken)
Wang Y, Liu X, Xie G, Li Z.
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Identification of Promising Candidate Genes and Immune Infiltration Patterns in Chronic Schistosomiasis-Associated Liver Injury by WGCNA and Machine Learning. [PDF]

Pathogens
Li Y, Li Q, Guo S, Li S, Xu J.
europepmc   +1 more source

Editorial: Immune infiltration and immunotherapy in cancer studies

Frontiers in Molecular Biosciences
Udayan Bhattacharya, Pooja Chauhan, Manish Goyal   +2 more
openaire   +3 more sources

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Expression of lactylation-related genes and their correlation with diabetic foot ulcer occurrence and immune infiltration. [PDF]

Front Immunol
Hu X, Zhou J, Guo M, Peng W, Yang C, Wang F, Zhang W, Liu J.   +7 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Roles of m6A regulators in shaping methylation patterns and tumor microenvironment immune infiltration in colorectal cancer. [PDF]

Discov Oncol
Zhang CQ, Ma JW, Xu F, Meng FL, Yang N, Zhang X, Zhao QW, Li W, Zhao ZR.   +8 more
europepmc   +1 more source

RHBDD2 is involved in immune infiltration of colorectal adenocarcinoma

Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology
Fengchen Liu, Dongcheng Qin, Dewang Wu, Haoyu Tian, Wenbo Zhang, Changyun Huang, Jun Zhou, Fengwu Qiu   +7 more
openaire   +2 more sources