Results 21 to 30 of about 662,585 (256)

Immune infiltrate in cancer

Aging, 2015
The past decade has witnessed a major revolution in cancer research. While malignancy was (and is) generally considered as a cell-autonomous genetic and epigenetic disease, it turned out that cancer has also an immunological connotation [1]. Only if the immune system fails to eliminate the (pre-)neoplastic cells cancer can emerge and progress.
Gautier, Stoll, Laurence, Zitvogel, Guido, Kroemer   +2 more
openaire   +2 more sources

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system.
Azad, Abul, D'Costa, Zenobia, Diana, Angela, Dushek, Omer, Fokas, Emmanouil, Jones, Keaton, Kruger, Philipp, Liu, Stanley, McKenna, W. Gillies, Muschel, Ruth J., Sansom, Owen J., Yin Lim, Su   +11 more
core   +1 more source

Immune infiltration and immunophenotyping in atrial fibrillation

Aging, 2023
الرجفان الأذيني هو اضطراب نظم شائع نسبيًا في الممارسة السريرية. على الرغم من إحراز تقدم كبير في علاج الرجفان الأذيني والمضاعفات المرتبطة به، إلا أن الأبحاث حول الوقاية من الرجفان الأذيني متخلفة، ويرجع ذلك أساسًا إلى عدم وجود فهم عميق للتسبب في الرجفان الأذيني.
Yuqing Tian, Shiying Liu, Yanan Zhang, Jiefu Yang, Peiyao Guo, Hongchao Zhang, Yu Xue, Tong Zou   +7 more
openaire   +2 more sources

The immune phenotypes and different immune escape mechanisms in colorectal cancer

Frontiers in Immunology, 2022
The tumor microenvironment (TME) plays a crucial role in tumor progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) and the underlying immune escape mechanism have not been studied sufficiently.
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Qi Lin, Wentao Tang, Wentao Tang, Dexiang Zhu, Dexiang Zhu, Meiling Ji, Meiling Ji, Guodong He, Guodong He, Qingyang Feng, Qingyang Feng, Jianmin Xu, Jianmin Xu   +22 more
doaj   +1 more source

Immune infiltration, glioma stratification, and therapeutic implications [PDF]

Translational Cancer Research, 2016
By definition, gliomas are brain tumors emanating from glial precursor cells. Gliomas include glioblastoma (GBM), astrocytoma, oligodendroglioma, and ependymoma. The World Health Organization (WHO) traditionally classifies brain tumors according to their pathological features, with GBM having the highest grade (IV), while lower grades (mostly II, III ...
Manny D, Bacolod, Sarmistha, Talukdar, Luni, Emdad, Swadesh K, Das, Devanand, Sarkar, Xiang-Yang, Wang, Francis, Barany, Paul B, Fisher   +7 more
openaire   +2 more sources

Immune Cell Infiltrate and Prognosis in Gastric Cancer [PDF]

Cancers, 2020
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade.
Niko Kemi, Niko Hiltunen, Juha P. Väyrynen, Vesa-Matti Pohjanen, Olli Helminen, Anna Junttila, Johanna Mrena, Jan Böhm, Heikki Huhta, Joni Leppänen, Tuomo J. Karttunen, Joonas H. Kauppila   +11 more
openaire   +3 more sources

WHSC1/NSD2 regulates immune infiltration in prostate cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2021
BackgroundImmunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because of its limited immune infiltration. Tumor-resident immune cells have been detected in the prostate, but the regulatory mechanisms that govern tumor infiltration are still poorly understood.
Muzamil Y Want, Takemasa Tsuji, Prashant K Singh, James L Thorne, Junko Matsuzaki, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Richard C. Koya, Amit Lugade, Kunle Odunsi, Sebastiano Battaglia   +11 more
openaire   +5 more sources

Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma

Frontiers in Immunology, 2020
Background: The tumor microenvironment (TME) consists of heterogeneous cell populations, including malignant cells and nonmalignant cells that support tumor proliferation, invasion, and metastasis through extensive cross talk.
Shuguang Zuo, Min Wei, Shiqun Wang, Jie Dong, Jiwu Wei, Jiwu Wei   +5 more
doaj   +1 more source

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Infiltration of tumor spheroids by activated immune cells

Physical Biology, 2022
Abstract Recent years have seen a tremendous growth of interest in understanding the role that the adaptive immune system could play in interdicting tumor progression. In this context, it has been shown that the density of adaptive immune cells inside a solid tumor serves as a favorable prognostic marker across different types of ...
Mrinmoy Mukherjee, Oleksandr Chepizhko, Maria Chiara Lionetti, Stefano Zapperi, Caterina A. M. La Porta, Herbert Levine   +5 more
openaire   +4 more sources