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Gut microenvironment and immune function
Current Opinion in Clinical Nutrition and Metabolic Care, 1999Overreaction of the acute phase response is responsible for the two major complications to surgery, sepsis and thrombosis, but also most likely for the leading sequela to surgery, adhesion formation. The gastrointestinal tract, especially the colon, is a major player in the acute phase response and responsible for important immune functions with ...
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Immune Cells Within the Tumor Microenvironment
2013A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment.
ZOLLO, MASSIMO, SPANO, DANIELA
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A scaffold immune microenvironment
Science, 2016Local immune cells create conditions that support tissue regeneration [Also see Report by Sadtler et al. ]
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Immune checkpoints in the tumor microenvironment
Seminars in Cancer Biology, 2020Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Salman M, Toor +3 more
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Exosomes Function in Tumor Immune Microenvironment
2018Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing "signals" released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression.
Yin, Huang +4 more
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Immune Suppression in the Tumor Microenvironment
Journal of Immunotherapy, 2006The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski +2 more
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Structural Correlates of Immune Microenvironment
1973In this introductory note I should just like to make a few general remarks on the importance of lymphatic cell morphology, the necessity for the theoretical approaches to the study of immune response, and the existence of many connections among apparently different tissues, to sketch the principal components of the microenvironment of lymphatic tissue ...
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Immune Cell Metabolism in Tumor Microenvironment
2017Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell
Yongsheng, Li, Yisong Y, Wan, Bo, Zhu
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Immune Microenvironment in Breast Cancer Metastasis
Metastatic disease is the final stage of breast cancer that accounts for vast majority of patient death. Mounting data over recent years strongly support the critical roles of the immune microenvironment in determining breast cancer metastasis. The latest single-cell studies provide further molecular evidence illustrating the heterogeneity of this ...Bin-Zhi, Qian, Ruo-Yu, Ma
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The rewired immune microenvironment in leukemia
Nature ImmunologyLeukemias are a class of human cancers that originate from hematopoietic progenitors and are characterized by extensive remodeling of the immune microenvironment. Leukemic cells, on transformation, acquire the ability to evade immune recognition but, despite undergoing genetic and epigenetic changes, retain their characteristic immature immune ...
Zoe Ciantra +2 more
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