Results 191 to 200 of about 128,938 (315)

Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change

open access: yesBioEssays, EarlyView.
Cell shape changes underlie animal development, physiology, and disease. The cell surface is mechanosensitive to the microenvironment and cytoskeleton activities, which generate plasma membrane topographies recognized and affected by Arp2/3 actin network induction pathways to remodel cell shape during immune cell migration, neural progenitor cell ...
Tony J. C. Harris
wiley   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

open access: yesCancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan   +13 more
wiley   +1 more source

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

open access: yesSmall, Volume 18, Issue 51, December 22, 2022., 2022
Hyaluronic acid (HA) is a very promising polysaccharide for biomedical applications. This review provides a comprehensive overview of the development of nanoparticulate systems by HA‐based polyelectrolyte complexation. The main achievements and applications for the delivery of active substances or the construction of multifunctional platforms are ...
Huu Van Le, Didier Le Cerf
wiley   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

open access: yesCancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang   +6 more
wiley   +1 more source

Folate Receptor‐Mediated Delivery of Cas9 RNP for Enhanced Immune Checkpoint Disruption in Cancer Cells

open access: yesSmall, Volume 19, Issue 2, January 11, 2023., 2023
For therapeutic genome editing, efficient and cell‐specific transport of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) system into target cells is desirable. Here, folic acid‐modified Cas9 ribonucleoprotein nanocarriers are presented, which mediate enhanced gene modification in folate receptor
Yi Lin   +8 more
wiley   +1 more source

Mycobacterial Antigen Driven Activation of CD14++CD16- Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. [PDF]

open access: yes, 2014
Anbalagan, S   +18 more
core   +1 more source

Scrambled RGD Hexameric Peptide Hydrogel Supports Efficient Self‐Assembly and Cell Activity

open access: yesChemistry – A European Journal, EarlyView.
Self‐assembled peptide hydrogels that incorporate bioactive motifs such as the integrin‐binding epitope Arginine‐Glycine‐Aspartic acid (RGD), are known for supporting cell growth. Surprisingly, scrambling the peptide cell‐adhesion motif RGD to RDG in an Fmoc‐hexapeptide peptide gelator (Fmoc‐GFFRGD) results in superior properties in terms of minimum ...
Karrar Al Taief   +4 more
wiley   +1 more source

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