Results 91 to 100 of about 78,926 (342)

Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets [PDF]

, 2017
Background: HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS).
A Antinori, A Guihot, A Horta, A Lim, AL Kinter, Ana Horta, AR Dinardo, C Chang, C Lang, C Manzardo, Claudia Nobrega, D Filisetti, DH Kung, EM Aandahl, Eugénia Reiriz, F Simonetta, FJ Mateen, G Carcelain, G Martin-Blondel, G Martin-Blondel, G Meintjes, G Pfeffer, HTT Tran, IM Rea, IW Tremont-Lukats, J Lopez-Abente, J Quick-Weller, KA Wilkinson, L Shahani, L Weiss, LR Antonelli, M Chachage, M Müller, MA French, MAH French, Margarida Correia-Neves, ME Moreno-Fernandez, MF Chevalier, MP Eggena, N Blanchard, N Seddiki, NF Walker, P Pean, RF Cabral, Rita Rb-Silva, Rui Sarmento-Castro, S Elahi, Soraia Almeida, SZ Josefowicz, T Johnson, Y Jiao, YD Mahnke   +51 more
core   +3 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Immune reconstitution inflammatory syndrome associated with acquired immunodeficiency syndrome-related gastrointestinal limited Kaposi's sarcoma presenting as acute intestinal obstruction: a case report

Journal of Medical Case Reports, 2011
Introduction Immune reconstitution inflammatory syndrome during anti-retroviral treatment of acquired immunodeficiency syndrome (AIDS) -associated gastrointestinal Kaposi's sarcoma has rarely been reported.
Pathak Hari, Shrivastav Ankit, Pal Jyotirmoy, Sarkar Dipendra   +3 more
doaj   +1 more source

Acute Renal Failure on Immune Reconstitution in an HIV-Positive Patient with Miliary Tuberculosis [PDF]

, 2017
Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. We describe a patient with
Battegay, Manuel, Dickenmann, Michael, Glatz-Krieger, Katharina, Hirsch, Hans H., Jehle, Andreas W., Khanna, Nina, Sigle, Jörg-Peter, Steiger, Jürg   +7 more
core  

Subtle Cryptococcal Immune Reconstitution Inflammatory Syndrome [PDF]

Cureus, 2019
Patients with HIV and opportunistic infections (OIs), such as tuberculosis and cryptococcosis, have been recognised to have immune reconstitution inflammatory syndrome (IRIS) following initiation of highly active antiretroviral therapy (HAART). The initiation of HAART boosts CD4 T cells, which result in exacerbations of OIs.
openaire   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Tuberculosis IRIS: a mediastinal problem [v2; ref status: indexed, http://f1000r.es/1e5]

F1000Research, 2013
We present a case of a 39 year old male patient with Acquired Immune Deficiency Syndrome (AIDS) who developed Mycobacterium tuberculosis related Immune Reconstitution Inflammatory Syndrome (IRIS) after initiation of Highly Active Antiretroviral Therapy ...
Leonardo Valentin, Andrew DiNardo, Elizabeth Chiao, Laila Woc-Colburn, Arun Nachiappan   +4 more
doaj   +1 more source

Impact of Human Immunodeficiency Virus in the Pathogenesis and Outcome of Patients with Glioblastoma Multiforme. [PDF]

, 2016
BackgroundImprovement in antiviral therapies have been accompanied by an increased frequency of non-Acquired Immune Deficiency Syndrome (AIDS) defining malignancies, such as glioblastoma multiforme.
Bui, Timothy T, Choy, Winward, Lagman, Carlito, Lee, Seung J, Safaee, Michael, Yang, Isaac   +5 more
core   +1 more source

Clinical and immunologic predictors of Mycobacterium avium complex immune reconstitution inflammatory syndrome in a contemporary cohort of patients with HIV.

Journal of Infectious Diseases, 2020
BACKGROUND Patients with HIV (PWH) can present with new or worsening symptoms associated with Mycobacterium avium complex (MAC) infection shortly after antiretroviral therapy (ART) initiation as MAC immune reconstitution inflammatory syndrome (MAC-IRIS).
Kimberly F. Breglio, Caian L. Vinhaes, M. Arriaga, M. Nason, G. Roby, J. Adelsberger, B. Andrade, V. Sheikh, I. Sereti   +8 more
semanticscholar   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source