Results 91 to 100 of about 43,379 (243)

The Epidemiology of IRIS in Southern India: An Observational Cohort Study

Journal of the International Association of Providers of AIDS Care, 2017
Immune reconstitution inflammatory syndrome (IRIS) is an uncommon but dynamic phenomenon seen among patients initiating antiretroviral therapy (ART). We aimed to describe incidence, risk factors, clinical spectrum, and outcomes among ART-naive patients ...
Nisha Thambuchetty MBBS, Kayur Mehta MD, Karthika Arumugam MSc, Umadevi G. Shekarappa MBBS, Jyothi Idiculla MD, MRCP, Anita Shet MD, PhD   +5 more
doaj   +1 more source

The potential for therapeutic drug monitoring of belatacept and other biologicals in solid organ transplantation

British Journal of Clinical Pharmacology, EarlyView.
Abstract In solid organ transplantation (SOT), biologicals such as recombinant therapeutic proteins, monoclonal antibodies, fusion proteins and conjugates are increasingly used for immunosuppression, desensitization, ABO (blood group) incompatibility, antibody‐mediated rejections and atypical haemolytic uremic syndrome.
Stein Bergan, Nils Tore Vethe
wiley   +1 more source

Neurological manifestations of cytomegalovirus infection with immune reconstitution syndrome in patients with poorly-controlled HIV

PAMJ Clinical Medicine, 2020
Cytomegalovirus reactivation is a complication of advanced HIV disease, with the main manifestation being retinitis. Other neurological manifestations are quite rare. The immune reconstitution syndrome has been reported, mainly as a uveitis.
Karishma Sharma, Felix Riunga, Dilraj Singh Sokhi   +2 more
doaj   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

British Journal of Haematology, EarlyView.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu, Chenfei Liu, Lezong Chen, Xumiao Zhang, Yinglin Su, Zhenzhen Chou, Yang Liang, Yuanbin Song   +7 more
wiley   +1 more source

Chylous Ascites in a Patient with HIV/AIDS: A Late Complication of Mycobacterium avium Complex-Immune Reconstitution Inflammatory Syndrome

Case Reports in Infectious Diseases, 2014
Chylous ascites is very rare in HIV/AIDS and its association with Mycobacterium avium complex-immune reconstitution inflammatory syndrome (MAC-IRIS) has been rarely reported.
Imam H. Shaik, Fernando Gonzalez-Ibarra, Rumana Khan, Saira Shah, Amer K. Syed, David Lintz   +5 more
doaj   +1 more source

Immune reconstitution inflammatory syndrome associated with pulmonary pathogens

European Respiratory Review, 2017
Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune system in HIV-infected patients.
Radha Gopal, Rekha R. Rapaka, Jay K. Kolls   +2 more
doaj   +1 more source

A stochastic chemical dynamic approach to correlate autoimmunity and optimal vitamin-D range [PDF]

, 2014
Motivated by several recent experimental observations that vitamin-D could interact with antigen presenting cells (APCs) and T-lymphocyte cells (T-cells) to promote and to regulate different stages of immune response, we developed a coarse grained kinetic model in an attempt to quantify the role of vitamin-D in immunomodulatory responses.
arxiv   +1 more source

Indirect presentation of mismatched human leukocyte antigen‐B associates with outcomes of cord blood transplantation

British Journal of Haematology, EarlyView.
This study analysed 1498 single‐unit cord blood transplantation (CBT) cases (2000–2018) to evaluate the impact of mismatched human leukocyte antigen (HLA) immunogenicity. Results highlighted that Class I epitopes from recipient‐mismatched HLA‐B were associated with higher transplantation‐related mortality (TRM) and lower neutrophil engraftment ...
Takeshi Sugio, Kohta Miyawaki, Naoyuki Uchida, Matthias Niemann, Eric Spierings, Kyohei Mori, Yuju Ohno, Tetsuya Eto, Yasuo Mori, Goichi Yoshimoto, Yoshikane Kikushige, Yuya Kunisaki, Shinichi Mizuno, Koji Nagafuji, Hiromi Iwasaki, Tomohiko Kamimura, Ryosuke Ogawa, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi, Koji Kato   +20 more
wiley   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Condyloma Overgrowth Caused by Immune Reconstitution Inflammatory Syndrome [PDF]

, 2009
A 46-year-old man with human immunodeficiency virus presented with a condyloma that formed during 6 months and encased his penis, scrotum, and perineum.
Breyer, Benjamin N, Myers, Jeremy B, Weiss, Dana A, Yang, Glen   +3 more
core   +1 more source