Results 191 to 200 of about 78,926 (342)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, Volume 13, Issue 6, 30 January 2026.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Immune reconstitution inflammatory syndrome in AIDS-related non-hodgkin′s lymphoma

Indian Journal of Medical and Paediatric Oncology, 2009
Immune Reconstitution syndrome following antiretroviral therapy is common in HIV/AIDS patients due to boosting of immunity. A case is reported here wherein AIDS-related Non-Hodgkin′s lymphoma patient received CHOP regimen and antiretroviral ...
Phatak Uday
doaj  

Disseminated coccidioidomycosis in a patient who is immunocompromised in the setting of immune reconstitution inflammatory syndrome

, 2021
Hamid Yaqoob, Muhammad Munawar, Omer Salih, Anand Deonarine   +3 more
openalex   +2 more sources

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, Volume 13, Issue 4, 19 January 2026.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection [PDF]

, 2018
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals infected with HIV-1. It has long been known that HIV-1 infection alters the course of M.
Bell, LCK, Noursadeghi, M
core  

Tuberculoma development in tuberculosis immune reconstitution inflammatory syndrome in an infant [PDF]

, 2023
Alexandria E. Melendez‐Zaidi, Fábio A. Nascimento, Nikita Shukla, Thierry A. G. M. Huisman   +3 more
openalex   +1 more source

Cerebral Abscess Masquerading as Tuberculoma in a Post‐Renal Transplant Chronic Kidney Disease Patient: A Diagnostic and Therapeutic Challenge

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Solid organ transplant recipients are at increased risk of acquiring serious infections. We present a case of a 48‐year‐old male with a history of renal transplantation in 2012, chronic kidney disease (CKD) Stage 4, hypertension, uncontrolled diabetes mellitus, and prior tuberculous pleural effusion.
Sakib Abrar, Ibrahim Khalil, Md. Imran Hossain, Sunjida Amin Promi   +3 more
wiley   +1 more source

Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome Complicated by Large Bilateral Psoas Abscess: A Case Report

Journal of the International Association of Providers of AIDS Care
Immune reconstitution inflammatory syndrome is a common manifestation in human immunodeficiency virus (HIV)-positive patients infected with tuberculosis (TB). One of the unusual complications of this condition is the development of psoas abscess.
Adriam M. Castilla-Encinas MD, Valeria Rocio Soto Salas MD, Hugo Alvarez-Delgado MD, Jhon E. Bocanegra-Becerra MD, Paola L. Rondan MD   +4 more
doaj   +1 more source

To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era

, 2020
Maura Manion, Niamh Lynn, Luxin Pei, Dima A. Hammoud, Elizabeth Laidlaw, Gregg Roby, Dorinda Metzger, Yolanda Mejia, Andrea Lisco, Adrian M. Zelazny, Steven M. Holland, Marie-Louise Vachon, Matthew Scherer, Colm Bergin, Irini Sereti   +14 more
openalex   +2 more sources