Results 111 to 120 of about 1,062,719 (316)
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis [PDF]
, 2014 T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Xiuwei Zhang +32 more
core +1 more source
Immune regulation in renal inflammation
, 2021 Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also ...
Tiegs, Gisa, Neumann, Katrin
core +1 more source
Cutaneous Manifestations of Hyper IgE Syndrome
Allergology International, 2012 Hyper-IgE syndrome (HIES) is a primary immunodeficiency disorder characterized by atopic manifestations and susceptibility to infections with extracellular bacteria and fungi. Atopic manifestations include atopic dermatitis-like skin lesion and extremely
Yoshiyuki Minegishi, Masako Saito
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Immune Cell Responses to the Cattle Lungworm, Dictyocaulus viviparus [PDF]
, 2008 The cattle lungworm, Dictyocaulus viviparus, is a parasitic nematode, which can cause severe pulmonary disease. Repeated natural infections result in protective immunity, and a live attenuated vaccine exists.
Hagberg, Malin
core
RNA regulation in immunity [PDF]
Immunological Reviews, 2021 Heather, Pua, K Mark, Ansel
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2008 AIM: To determine the immunomodulatory effect of Shiitake (a mushroom extract), we tested its effect on liver-mediated immune regulation in a model of immune-mediated colitis. METHODS: Four groups of mice were studied. Colitis was induced by intracolonic
Hershcovici, T. +11 more
core +1 more source
CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]
, 2003 Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Maloy, Kevin +19 more
core +1 more source
Crucial Role for Basophils in Acquired Protective Immunity to Tick Infestation
Frontiers in Physiology, 2018 Ticks are blood-sucking arthropods that can transmit various pathogenic organisms to host animals and humans, causing serious infectious diseases including Lyme disease. Tick feeding induces innate and acquired immune responses in host animals, depending
Hajime Karasuyama +5 more
doaj +1 more source