Results 151 to 160 of about 1,393,861 (205)

Immune Mechanisms of Corneal Allograft Rejection

Current Eye Research, 2007
Penetrating keratoplasty has been successfully performed on humans for over 100 years and remains the most common form of solid tissue transplantation. Although corneal allografts enjoy a remarkable degree of immune privilege, immune rejection remains the leading cause of keratoplasty failure.
Jerry Y Niederkorn
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Immune Mechanisms of Acute Rejection

Transplantation Proceedings, 1998
An understanding of acute allograft rejection has eluded investigators for many years, despite major research efforts in this area. This understanding may not be achievable, given the current philosophic approach to the study of immune processes. An alternative approach, which is outlined here, would require investigators to develop an appreciation for
C G, Orosz, A M, VanBuskirk
openaire   +2 more sources

Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation

Frontiers in Immunology, 2023
International audienceBackground : Acute rejection persists as a frequent complication after kidney transplantation. Defining an at-risk immune profile would allow better preventive approaches.
Emilie Gaiffe, Jamal Bamoulid, Philippe Saas   +2 more
exaly   +2 more sources

Cytokines in Immunity and Allograft Rejection

Critical Reviews™ in Immunology, 2002
Cytokines are highly potent regulatory molecules that are secreted by a variety of cells into the local microenvironment. These chemical messengers participate in the activation and regulation of immune function by a variety of mechanisms, including the stimulation and inhibition of cellular proliferation and differentiation.
Louis C, Benjamin, James S, Allan, Joren C, Madsen   +2 more
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Innate immunity and graft rejection

Immunological Reviews, 2000
Summary: Although innate immunity evolved to combat pathogens, increasing awareness of a pivotal role in driving and shaping adaptive immunity has prompted this review on the role of innate immunity in graft rejection. We present evidence that grafts, especially xenografts, elicit innate responses, required for adaptive immunity.
A, Fox, L C, Harrison
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Immune mechanisms of acute and chronic rejection

Clinical Biochemistry, 2016
With the currently available immunosuppression, severe T-cell mediated rejection has become a rare event. With the introduction of modern antibody-detection techniques, such as the L-SAB technology, acute or hyperacute antibody-mediated rejection of the kidney are also seen infrequently. In contrast, chronic antibody-mediated rejection is considered to
Luis Eduardo, Becker, Christian, Morath, Caner, Suesal   +2 more
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Chronic rejection failure of immune regulation

Frontiers in Bioscience, 2003
Current strategies for immunosuppression following organ transplantation focus on the prevention of acute rejection. As new generations of immunosuppressants have been developed, acute rejection rates have diminished markedly. The new challenge, then, is to prevent the devastating complications of chronic rejection, which have remained largely ...
Jeremy, Goodman, Thalachallour, Mohanakumar   +1 more
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Innate immunity in transplant tolerance and rejection

Immunological Reviews, 2011
Summary:  Historically, research on transplant rejection and tolerance has focused on cells of the adaptive immune system, especially T cells. Anti‐graft effector T cells are necessary and sufficient for the rejection of most allografts, while regulatory T cells, either arising naturally or as a result of a specific treatment regimen, are crucial to ...
Shaun P, Murphy, Paige M, Porrett, Laurence A, Turka   +2 more
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Immune Mechanisms of Lung Allograft Rejection

Seminars in Respiratory and Critical Care Medicine, 2006
Extended survival after lung transplantation is primarily limited by progressive airflow obstruction and fibrotic obliteration of the small airways, termed bronchiolitis obliterans syndrome (BOS) and bronchiolitis obliterans (BO), respectively. BO is thought to represent the pulmonary-specific manifestation of chronic allograft rejection and the end ...
Laurie D, Snyder, Scott M, Palmer
openaire   +2 more sources

Molecular Imaging of Innate Immune Cell Function in Transplant Rejection

Circulation, 2009
BACKGROUND: Clinical detection of transplant rejection by repeated endomyocardial biopsy requires catheterization and entails risks. Recently developed molecular and cellular imaging techniques that visualize macrophage host responses could provide a ...
Elena Aikawa, Peter Libby, Filip Swirski   +2 more
exaly   +1 more source