Results 171 to 180 of about 1,393,861 (205)
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Corneal Immune Rings Associated With Heterograft Rejection
Archives of Ophthalmology, 1965It has been shown experimentally that the cornea is capable of supporting two types of hypersensitivity phenomena. 1 The first type appears to be mediated by immunologically competent mononuclear cells, the second type by circulating antibodies. When a soluble protein antigen is used to sensitize the cornea, the cellular-mediated response is manifest ...
J H, ELLIOTT, H M, LEIBOWITZ
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Immunity of Allograft Rejection: An Overview
2004Transplantation between genetically disparate individuals of the same species evokes numerous changes in the host and the graft. In general, the outcome of a transplanted organ is determined by two closely interrelated components. The first component is the biology of the foreign graft (i.e., type of organ and its macro-and microenvironments, the ...
Worakij Chalermskulrat +2 more
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Immune-Mediated Tumor Rejection
2010Fundamental strides in the understanding of the molecular basis of tumor rejection were made in the last decade thanks to observational studies performed at relevant time points in human cancerous tissues. The following concepts emerged: immune surveillance against tumors is a likely occurrence.
Ena Wang, Francesco M. Marincola
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EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER
International Journal of Oncology, 1995A cellular cancer therapy is described with unique efficiency even in late-stage disease. in situ activated tumor-immune T cells, induced in allogeneic, tumor-resistant, MHC identical but superantigen different donor mice (B10.D2) could transfer strong graft-versus-leukemia (GvL) effects accompanied by only mild graft-versus-host (GvH) reactivity ...
V, Schirrmacher +10 more
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Systemic and Local Immunity in Allograft and Cancer Rejection
1978Studies of allograft and tumor rejection have historically been closely related. Indeed, many of thestudies on tumor immunity carried out in theearly part of this century actually dealt with tumor allograft rejection, and theconcepts derived from transplantation immunity studies have provided many useful models and concepts for tumor immunology.
J S, Haskill, P, Häyry, L A, Radov
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Dendritic cells and cytokines in immune rejection of cancer
Cytokine & Growth Factor Reviews, 2008Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity and, thus, in the generation of a protective immune response against both infectious diseases and tumors. The ability of DCs to prime and expand an immune response is regulated by signals acting through soluble mediators, mainly cytokines and chemokines. Understanding how
Maria, Ferrantini +2 more
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IgM Participation in Tumor Rejection by Immunized MICE
Tumori Journal, 1977IgG and IgM participation in tumor rejection was studied in DBA/2 mice immunized against L1210 leukemia and in Swiss mice immunized against Ehrlich adenocarcinoma. In both the systems, IgM globulins seem to be implicated and are present on the cell surface of macrophages, lymphocytes and cancer cells, while IgG globulins are present only on some ...
L, Bellelli, A, Nista, M L, Sezzi
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Accelerated Graft Rejection in the Offspring of Immunized Mothers
The Journal of Immunology, 1965Summary Infant rats born of mothers sensitized prior to and during pregnancy displayed a) a state of delayed hypersensitivity as manifested by skin reactions to tuberculin in 26% of animals born of mothers immunized with tubercle bacilli and b) a state of homograft immunity manifested by accelerated rejection of donor homografts in ...
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Immune effector mechanisms in heart transplant rejection
Cardiovascular Research, 1994It is well established that immunological mechanisms are responsible for the pathophysiology of several heart diseases, some contributing significantly to morbidity and mortality worldwide. Of the multiple cellular and humoral components participating in the overall immune response in heart diseases, this article mainly deals with cellular immunity ...
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Preventing Immune Rejection Through Gene Silencing
2010Dendritic cells (DCs) comprise a family of professional antigen-presenting cells responsible for the induction of primary immune responses. DCs are also important for the induction of immunological tolerance. Recent research has revealed that DC maturation is associated with activation of the NF-kappaB pathway.
Xusheng, Zhang, Mu, Li, Wei-Ping, Min
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