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VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
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VIEW, EarlyView.This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu +10 more
wiley +1 more source
Epstein‐Barr virus as a driver of lupus: Rethinking triggers in autoimmunity
Rheumatology &Autoimmunity, EarlyView.
Jiekai Tan, Fanlei Hu, Chuanhui Xu
wiley +1 more source
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Fractal representation of the immune B cell repertoire
BioSystems, 1996The immune repertoire is characterized by a complex and dynamic organization. Here I suggest, based on the presence of well-defined immune reactivity patterns (RP) analyzed using a linguistic analogy, that the B cell repertoires could possess a fractal structure.
exaly +3 more sources
Beyond Natural Immune Repertoires: Synthetic Antibodies
Cold Spring Harbor Protocols, 2023Synthetic antibody libraries, in which the antigen-binding sites are precisely designed, offer unparalleled precision in antibody engineering, exceeding the potential of natural immune repertoires and constituting a novel generation of research tools and therapeutics.
Gianluca, Veggiani, Sachdev S, Sidhu
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Investigation of immune repertoires in thymoma.
Journal of Clinical Oncology, 2020e21117 Background: Paraneoplastic autoimmune manifestations are seen in 30 to 40% of thymoma cases. Thymus plays the main role in T- cell maturation with ‘negative selection’ of autoreactive T-cells. Due to reasons not well understood, this function is deranged in thymomas resulting in dysregulation of immune function, loss of ‘self-tolerance’ and ...
Priyadarshini Pathak +3 more
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Immune repertoire profiling in myasthenia gravis
Immunology & Cell BiologyAbstractMyasthenia gravis (MG) is the most frequent immune‐mediated neurological disorder, characterized by fluctuating muscle weakness. Specific recognition of self‐antigens by T‐cell receptors (TCRs) and B‐cell receptors (BCRs), coupled with T–B cell interactions, activates B cells to produce autoantibodies, which are critical for the initiation and ...
Ting, He +4 more
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A dynamical model for the immune repertoire
Physica A: Statistical Mechanics and its Applications, 2001zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lagreca, M. C. +2 more
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Single-cell immune repertoire analysis
Nature MethodsSingle-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. However, it has been extremely challenging to analyze and interpret T cells and B cells and their adaptive
Sergio E. Irac +3 more
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