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Application of immune repertoire sequencing in cancer immunotherapy
International Immunopharmacology, 2019With the prominent breakthrough in the field of tumor immunology, diverse cancer immunotherapies have attracted great attention in the last decade. The immune checkpoint inhibitors, adoptive cell therapies, and therapeutic cancer vaccines have already achieved impressive clinical success.
Yuan, Zhuang +5 more
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Host Immune Repertoire and Infection
2018The human immune repertoire is defined as the totality of T and B cells with functional diversity in the human circulatory system at any given time; this repertoire is based on the most diverse portion of T and B cell receptors known as the complementarity-determining regions (CDRs). This immune repertoire is a dynamic pool that reflects the essence of
Dongni Hou, Jieming Qu, Yuanlin Song
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Qualifying high-throughput immune repertoire sequencing
Cellular Immunology, 2014Diversity of B and T cell receptors, achieved by gene recombination and somatic hypermutation, allows the immune system for recognition and targeted reaction against various threats. Next-generation sequencing for assessment of a cell's gene composition and variation makes deep analysis of one individual's immune spectrum feasible. An easy to apply but
Norbert Niklas +7 more
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Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires
Trends in Immunology, 2015High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative analysis of adaptive immune responses and offers the potential to revolutionize research in lymphocyte biology, vaccine profiling, and monoclonal antibody engineering.
Greiff Victor +3 more
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Towards error-free profiling of immune repertoires
Nature Methods, 2014Deep profiling of antibody and T cell-receptor repertoires by means of high-throughput sequencing has become an attractive approach for adaptive immunity studies, but its power is substantially compromised by the accumulation of PCR and sequencing errors.
Mikhail Shugay +15 more
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Genetic control of the immune repertoire in nematode infections
Parasitology Today, 1989Mammals vary considerably, both within and between species, in the way in which their innate and adaptive immune systems respond to infections. An understanding of the processes involved in such variability will not only contribute to explaining heterogeneity in susceptibility and pathology, but will also be relevant to vaccination.
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Somatic mutation: Diversity and regulation of the immune repertoire
Cell, 1987Accounting for the enormous diversity of the immune response has been the underlying question of immunology since Paul Ehrlich first addressed it in 1900. The problem has at least two facets: the genetic organization and the nature of the cells that carry out the immune response.
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Moringa oleifera polysaccharide regulates colonic microbiota and immune repertoire in C57BL/6 mice
International Journal of Biological Macromolecules, 2022Hanchen Tian, Guangbin Liu, Yaokun Li
exaly
Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases
Autoimmunity, 2021Ming Zhao, Haijing Wu, Qianjin Lu
exaly