Results 81 to 90 of about 106,980 (248)
The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma
Journal of Translational MedicineBackground Esophageal squamous cell carcinoma (ESCC) is a malignant neoplasm with detrimental implications for human health. The landscape of ESCC therapy has been revolutionized by the introduction of immunotherapy, specifically involving immune ...
Meng Yang +6 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Frontiers in Immunology, 2017 The inaugural workshop “Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes” was held in Singapore on 13–14 October 2016.
William F. Burkholder +4 more
doaj +1 more source
Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening
Advanced Science, EarlyView.Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun +6 more
wiley +1 more source
Response to “Wearable Remote Monitoring and COVID‐19”
Clinical and Translational Science, 2022 Elena S. Izmailova, Theodore F. Reiss
doaj +1 more source
HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer
Frontiers in ImmunologyBackgroundT and B cells are central to adaptive immunity, where they identify and neutralize foreign antigens and cancer neo−antigens. Large−scale elucidation of T− and B−cell receptors (TCRs and BCRs) through immune−repertoire sequencing promises novel ...
Vahid Akbari +26 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
Advanced Science, EarlyView.A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao +9 more
wiley +1 more source