Results 91 to 100 of about 2,062,013 (251)

Supplementary Data from Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

, 2022
Supplementary Data from Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast ...
Sylvain Baulande (5113562), Vassili Soumelis (6630929), Eleonora Timperi (14961185), Paul Gueguen (14961188), Anne Tardivon (9335882), Yann Kieffer (14961197), Ilaria Magagna (14961194), Gabriel Champenois (14961206), Silvia Lopez-Lastra (14961200), Philemon Sirven (14961203), Martina Molgora (14961191), Anne Vincent-Salomon (14961209), Marco Colonna (14961212), Laura G. Baudrin (12362098), Sebastian Amigorena (14692960), Emanuela Romano (14961215), André Nicolas (259278), Didier Meseure (666209), Enora Laas (2146114), Fatima Mechta-Grigoriou (9123101)   +19 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Supplementary Figure Legends from BRAF Inhibition Alleviates Immune Suppression in Murine Autochthonous Melanoma

, 2014
Supplementary Figure Legends from BRAF Inhibition Alleviates Immune Suppression in Murine Autochthonous ...
Tamer B. Shabaneh (13934772), Marc S. Ernstoff (9279998), Shannon M. Steinberg (14929737), Constance E. Brinckerhoff (14883743), Marcus W. Bosenberg (8436153), Peisheng Zhang (341086), Andrea Boni (5384543), Mary Jo Turk (14909603), Katelyn T. Byrne (15113170), David W. Mullins (7008137), Brian T. Malik (14929740)   +10 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Molecular mechanism of jet fuel induced immune suppression

, 2008
Dermal exposure to jet fuel suppresses the immune response. Immune regulatory cytokines, and biological modifiers, including platelet activating factor, prostaglandin E2, and interleukin-10 have all been implicated in the pathway leading to ...
Ramos, Gerardo
core   +1 more source

Immune Cell Responses to the Cattle Lungworm, Dictyocaulus viviparus [PDF]

, 2008
The cattle lungworm, Dictyocaulus viviparus, is a parasitic nematode, which can cause severe pulmonary disease. Repeated natural infections result in protective immunity, and a live attenuated vaccine exists.
Hagberg, Malin
core   +1 more source

Monitoring of the Immune Dysfunction in Cancer Patients

Vaccines, 2016
Immunotherapy shows promising clinical results in patients with different types of cancer, but its full potential is not reached due to immune dysfunction as a result of several suppressive mechanisms that play a role in cancer development and ...
Saskia J. A. M. Santegoets, Marij J. P. Welters, Sjoerd H. van der Burg   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.

, 2007
In most models of blood-stage malaria infection, proinflammatory immune responses are required for control of infection and elimination of parasites.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Daniel G. Blount, Blount, Daniel G., J. Brian de Souza, Hafalla, Julius CR, De Souza, J. Brian, Kevin N. Couper, van Rooijen, Nico, Julius C. R. Hafalla, de Souza, J Brian, Eleanor M. Riley, Riley, Eleanor M., Couper, Kevin N., Hafalla, Julius C R, Nico van Rooijen   +16 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source