Results 171 to 180 of about 286,536 (215)

Trans-Presentation of IL-15 by IL15Rα Attenuates Tumor Immune Surveillance and Is Dispensable for IL-15-Dependent Tumor Growth Control. [PDF]

Cancers (Basel)
Rexhepi F, Ali Akbari S, Moradzad M, Khodayari S, Shukla A, Demontier E, Lucier JF, Armas Cayarga A, Allard-Chamard H, Ilangumaran S, Ramanathan S.   +10 more
europepmc   +1 more source

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF‐κB Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin‐like proteins mediating protein degradation, has not been fully elucidated in CAC ...
Yuqi Han, Yaru Xia, Weiquan Li, Jiaming Wu, Tiexi Yu, Diaoyi Tan, Daojia Miao, Wen Li, Xuejiao Dong, Jiemin Li, Yu Jiao, Guixiao Huang, Xiaoping Zhang, Hongmei Yang   +13 more
wiley   +1 more source

Methylation of DPP9 regulates immune surveillance in non-small cell lung cancer by promoting macrophage ferroptosis via WWP2 ubiquitination. [PDF]

Am J Cancer Res
Lin H, Chen Y, Wang N, Zhang S.
europepmc   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Innate Immune Surveillance and Recognition of Epigenetic Marks. [PDF]

Epigenomes
Wang Y.
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Immune Surveillance and Immune Escape in Cancer: Mechanisms and Immunotherapy. [PDF]

MedComm (2020)
Peng Y, Zhan L, Shi J, Wang J, Li Y, Sun X, Lv J, Yang H, Qiu Z, Liu X, Li C, Gong S, Jia W, Wang H, Zhao Y, Zhang B, Guo W, Guo J, Shang J, Zhou Q, Yang Y, Gao F.   +21 more
europepmc   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source

Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. [PDF]

Nat Commun
Ha J, Wang Y, Ma Y, Wu A, Dong S, Jeong SD, Edwards JL, Chang M, Chang YT, Wang X, Dufilho M, Najarro Torres M, McCabe S, Deng W, Grippin AJ, Weinberg JS, Raza SM, DeMonte F, McCutcheon IE, Prabhu S, Ferguson SD, Ene CI, Akdemir K, Basu S, Jindal S, Schrank BR, Hu J, Goswami S, Puduvalli VK, Lang FF, Huntoon K, Sharma P, Kim BYS, Jiang W.   +33 more
europepmc   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source