Results 191 to 200 of about 1,158,960 (278)

Mimicking the TCR immune synapse for improved CAR-T cell function. [PDF]

Cell Res
Enbar T, Tang L.
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

CD49d governs immune synapse formation through actin rearrangements and synchronizes BCR signaling in CLL.

Blood
Polcik L, Pethe A, Ashok D, Tissino E, Fernández-Rego A, Pozzo F, Danner DJ, Holst M, Martines C, Hofmann K, Dimovski AJ, Kissel S, Härzschel A, Li L, Bittolo T, Andrieux G, Haslauer T, Höpner JP, Zaborsky N, Greil R, Miething C, Duque-Afonso J, Köhler N, Boerries M, Bomben R, Duyster J, Grosse R, Gaidano G, Zamò A, Zucchetto A, Carrasco YR, Efremov DG, Gattei V, Hartmann TN.   +33 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation. [PDF]

Proc Natl Acad Sci U S A
Rodgers-Furones A, Brands T, van Gameren G, Florencio-Zabaleta M, Bathini M, Delgado S, Wijfjes Z, Fedorova K, Classens R, Kroese L, Verdoes M, van Mierlo G, Jiménez-Barbero J, Lindeboom RGH, Ardá A, van Spriel AB, Cano LQ.   +16 more
europepmc   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength. [PDF]

Cancer Immunol Res
Navin I, Dysthe M, Menon PS, Baumgartner C, Sauer T, Varadarajan N, Parihar R.   +6 more
europepmc   +1 more source

Probing supramolecular organisation at immune synapses

, 2007
McCann, F E, Suhling, K, Carlin, L M, Eleme, K, Yanagi, K, French, P M W, Phillips, D, Davis, D M   +7 more
openaire   +3 more sources

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny. [PDF]

Regen Ther
Zhang J, Sumide K, Kanie K, Ishikawa A, Yoshida M, Ishii T, Wang B, Kaneko S.   +7 more
europepmc   +1 more source