Results 171 to 180 of about 1,284,834 (277)

Spatial regulation of Lck activation at the CD8 immune synapse revealed by a FRET-Based biosensor. [PDF]

Cell Mol Life Sci
Meana C, San-José G, Balboa MA, Casas J.   +3 more
europepmc   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular Tethering and Immune Synapse Formation. [PDF]

Biomater Res
Kim S, Lee CE, Jangid AK, Kim K.
europepmc   +1 more source

Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. [PDF]

Nat Commun, 2023
Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M.   +15 more
europepmc   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor. [PDF]

Nat Commun
Tsai CT, Ibanez-Vega J, Yin P, Teis R, Watanabe N, Honda T, Valkov M, Chockley PJ, Madrigal LAJ, Krenciute G, Mamonkin M.   +10 more
europepmc   +1 more source

Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse. [PDF]

Science, 2023
Stinchcombe JC, Asano Y, Kaufman CJG, Böhlig K, Peddie CJ, Collinson LM, Nadler A, Griffiths GM.   +7 more
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

RASA2 deletion rescues immune synapse dysfunction, enhancing CAR T cell efficacy against DMGs. [PDF]

J Immunother Cancer
Ibanez-Vega J, Teis R, Ocasio JK, Chockley P, Ansari A, Allo Anido A, Mehta S, Meehl M, Prinzing B, Ward M, Odde D, Baker S, Krenciute G.   +12 more
europepmc   +1 more source

Vesicular traffic-mediated cell-to-cell signaling at the immune synapse in Ankylosing Spondylitis. [PDF]

Front Immunol, 2022
Tavasolian F, Pastrello C, Ahmed Z, Jurisica I, Inman RD.   +4 more
europepmc   +1 more source