Results 171 to 180 of about 1,158,960 (278)

Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular Tethering and Immune Synapse Formation. [PDF]

Biomater Res
Kim S, Lee CE, Jangid AK, Kim K.
europepmc   +1 more source

Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. [PDF]

Nat Commun, 2023
Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M.   +15 more
europepmc   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

RASA2 deletion rescues immune synapse dysfunction, enhancing CAR T cell efficacy against DMGs. [PDF]

J Immunother Cancer
Ibanez-Vega J, Teis R, Ocasio JK, Chockley P, Ansari A, Allo Anido A, Mehta S, Meehl M, Prinzing B, Ward M, Odde D, Baker S, Krenciute G.   +12 more
europepmc   +1 more source

Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse. [PDF]

Science, 2023
Stinchcombe JC, Asano Y, Kaufman CJG, Böhlig K, Peddie CJ, Collinson LM, Nadler A, Griffiths GM.   +7 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor. [PDF]

Nat Commun
Tsai CT, Ibanez-Vega J, Yin P, Teis R, Watanabe N, Honda T, Valkov M, Chockley PJ, Madrigal LAJ, Krenciute G, Mamonkin M.   +10 more
europepmc   +1 more source

Vesicular traffic-mediated cell-to-cell signaling at the immune synapse in Ankylosing Spondylitis. [PDF]

Front Immunol, 2022
Tavasolian F, Pastrello C, Ahmed Z, Jurisica I, Inman RD.   +4 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse. [PDF]

J Cell Biol, 2022
Wang MS, Huse M.
europepmc   +1 more source