Results 221 to 230 of about 73,161 (247)

The Immune Synapse: Past, Present, and Future

2017
Immunological synapses are specialized cell-cell junctions characterized by (1) close apposition of the immune cell membrane with the membrane of another cell driven by adaptive or innate immune recognition, (2) adhesion, (3) stability, and (4) directed secretion.
Dustin, Michael L., Baldari, Cosima
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APC, T Cells, and the Immune Synapse

2009
CD4(+) T cells engage different activating cells during their generation in the bone marrow and thymus and during their homeostasis and activation in the periphery. During these processes, T cells or their precursors establish a molecular platform for communication in the interface between the two cells that is called immune synapse (IS).
Reichardt, Peter, Dornbach, Bastian, Gunzer, Matthias   +2 more
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Immune synapses in T-cell activation

Current Opinion in Immunology, 2006
The contact site between T cells and antigen-presenting cells or T cells and their targets--the immunological synapse--is a highly specialized structure potentially involved in T-cell activation and function. Although many insights have been obtained since the initial description of the immune synapse, recent advances have provided us with a better ...
Saso, Cemerski, Andrey, Shaw
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Ultrastructure of Immune Synapses

2017
The immunological synapse is a critical event for immune response development. The use of planar supported bilayers as surrogate antigen-presenting cells is a useful tool to study this phenomenon. Here we describe electron microscopy methods and approaches to expand our knowledge of the events taking place during the initial phases of T cell activation
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Analysis of the kinomic and immune cancer synapse in GBM

2021
A deeper understanding of the signalling networks operating in vivo is needed to develop more physiologically relevant ex-vivo models and support the discovery of new therapeutics in human cancer. An example is human brain cancer where new therapeutics using essentially cancer cell models has failed to deliver therapeutic that work well in vivo.
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Dysfunctional Immune Synapses in T Cell Immunodeficiencies

2021
Adaptive immune responses take place in the T cell area of secondary lymphoid organs, where, on encounter of antigen-presenting cells (APCs) bearing specific MHC-associated antigen, T lymphocytes assemble a highly organized intercellular junction, referred to as the immune synapse, on which T cell activation, proliferation, and differentiation ...
Capitani, N., Patrussi, L., D'Elios, M. M., Baldari, C. T.   +3 more
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Analysis of TCR/CD3 Recycling at the Immune Synapse

2017
Engagement of the T cell antigen receptor (TCR) by specific ligand bound to the major histocompatibility complex is the primary event that leads to the assembly of the immune synapse (IS). Central to this process is TCR clustering at the T cell-APC contact, which is achieved with the contribution of an endosomal pool that is delivered to the IS by ...
Patrussi, Laura, Baldari, Cosima
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Actin' Up in the Immune Synapse

Science Signaling, 2003
A T cell engages an antigen presenting cell (APC) through a synaptic connection (the immune synapse) that subsequently controls T cell activation and function. This association recruits key actin regulatory proteins to the synapse, including Wiskott-Aldrich syndrome protein (WASP) and the small guanosine triphosphatase Cdc42, which ...
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Studying the Dynamics of TCR Internalization at the Immune Synapse

2017
Establishing a stable interaction between a T cell and an antigen presenting cell (APC) involves the formation of an immune synapse (IS). It is through this structure that the T cell can integrate all the signals provided by the APC. The IS also serves as a mechanism for TCR downregulation through internalization.
Enrique, Calleja, Balbino, Alarcón, Clara L, Oeste   +2 more
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Deacetylating Microtubules at the Immune Synapse

Science's STKE, 2004
T cell activation by antigen-presenting cells (APCs) involves formation of the immune synapse, a specialized junction characterized by supramolecular clusters of antigen receptors and other signaling molecules. Although the actin cytoskeleton has been implicated in this process, the role of microtubules in T cell activation is less well ...
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