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AGING MEDICINE, EarlyView.Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley +1 more source
Cytoskeletal Control of the Secretory Immune Synapse [PDF]
Current Opinion in Cell Biology, 2021 The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation.
Gillian Griffiths, Tiphaine Douanne
exaly +5 more sources
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Nanotubes at Neural and Immune Synapses
Current Medicinal Chemistry, 2008This minireview aims to demonstrate that (i) natural nanotubes play important roles in chemical signaling and (ii) they represent one of the deep functional similarities between neural and immune synapses. We also pay attention to the related receptor assemblies and possibilities of chemically synthesized carbon nanotubes to simulate functions of the ...
Larisa B, Goncharova +1 more
openaire +2 more sources
Inhibitory and Regulatory Immune Synapses
2009Cell contact-dependent inhibition and regulation of immune responses play an essential role in balancing the need for rapid and efficient responses to a wide variety of pathological challenges, while at the same time maintaining self-tolerance. Much attention has been given to immune synapses that lead to the activation of, for example, cell-mediated ...
Eissmann, Philipp, Davis, Daniel M.
openaire +2 more sources
Immune Synapse: Conductor of Orchestrated Organelle Movement [PDF]
Trends in Cell Biology, 2014 To ensure proper cell function, intracellular organelles are not randomly distributed within the cell, but polarized and highly constrained by the cytoskeleton and associated adaptor proteins. This relationship between distribution and function was originally found in neurons and epithelial cells; however, recent evidence suggests that it is a general ...
Francisco Sánchez Madrid +2 more
exaly +3 more sources