Results 241 to 250 of about 1,158,960 (278)

Mixed-mobility supported lipid bilayers reveal the modulatory role of immobilized ICAM1 on T cell activation, effector functions and immune synapse organization

Leithner A, Kvalvaag A, Mitra T, Valvo S, Dada H, Compeer E, Jenkins E, Lagerholm C, Dushek O, Dustin ML.   +9 more
europepmc   +1 more source

Cytoskeletal control of the secretory immune synapse [PDF]

Current Opinion in Cell Biology, 2021
The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation.
Gillian Griffiths, Tiphaine Douanne
exaly   +5 more sources

Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton [PDF]

Frontiers in Cell and Developmental Biology, 2021
Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lead to the reorganization of the cytoskeleton and ...
Francisco Sanchez-Madrid, José Valpuesta, Noa B Martin-Cofreces   +2 more
exaly   +6 more sources

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Nanotubes at Neural and Immune Synapses

Current Medicinal Chemistry, 2008
This minireview aims to demonstrate that (i) natural nanotubes play important roles in chemical signaling and (ii) they represent one of the deep functional similarities between neural and immune synapses. We also pay attention to the related receptor assemblies and possibilities of chemically synthesized carbon nanotubes to simulate functions of the ...
Larisa B, Goncharova, Alexander O, Tarakanov   +1 more
openaire   +2 more sources

Immune synapse: conductor of orchestrated organelle movement [PDF]

Trends in Cell Biology, 2014
To ensure proper cell function, intracellular organelles are not randomly distributed within the cell, but polarized and highly constrained by the cytoskeleton and associated adaptor proteins. This relationship between distribution and function was originally found in neurons and epithelial cells; however, recent evidence suggests that it is a general ...
Francisco Sanchez-Madrid, Francesc Baixauli, Noa Beatriz Martı́N-Cófreces   +2 more
exaly   +3 more sources

Inhibitory and Regulatory Immune Synapses

2009
Cell contact-dependent inhibition and regulation of immune responses play an essential role in balancing the need for rapid and efficient responses to a wide variety of pathological challenges, while at the same time maintaining self-tolerance. Much attention has been given to immune synapses that lead to the activation of, for example, cell-mediated ...
Eissmann, Philipp, Davis, Daniel M.
openaire   +2 more sources

Immune synapses in T-cell activation

Current Opinion in Immunology, 2006
The contact site between T cells and antigen-presenting cells or T cells and their targets--the immunological synapse--is a highly specialized structure potentially involved in T-cell activation and function. Although many insights have been obtained since the initial description of the immune synapse, recent advances have provided us with a better ...
Saso, Cemerski, Andrey, Shaw
openaire   +2 more sources