Results 251 to 260 of about 1,284,834 (277)

The Immune Synapse: Past, Present, and Future

2017
Immunological synapses are specialized cell-cell junctions characterized by (1) close apposition of the immune cell membrane with the membrane of another cell driven by adaptive or innate immune recognition, (2) adhesion, (3) stability, and (4) directed secretion.
Dustin, Michael L., Baldari, Cosima
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APC, T Cells, and the Immune Synapse

2009
CD4(+) T cells engage different activating cells during their generation in the bone marrow and thymus and during their homeostasis and activation in the periphery. During these processes, T cells or their precursors establish a molecular platform for communication in the interface between the two cells that is called immune synapse (IS).
Reichardt, Peter, Dornbach, Bastian, Gunzer, Matthias   +2 more
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Immune synapses in T-cell activation

Current Opinion in Immunology, 2006
The contact site between T cells and antigen-presenting cells or T cells and their targets--the immunological synapse--is a highly specialized structure potentially involved in T-cell activation and function. Although many insights have been obtained since the initial description of the immune synapse, recent advances have provided us with a better ...
Saso, Cemerski, Andrey, Shaw
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Ultrastructure of Immune Synapses

2017
The immunological synapse is a critical event for immune response development. The use of planar supported bilayers as surrogate antigen-presenting cells is a useful tool to study this phenomenon. Here we describe electron microscopy methods and approaches to expand our knowledge of the events taking place during the initial phases of T cell activation
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Actin' Up in the Immune Synapse

Science Signaling, 2003
A T cell engages an antigen presenting cell (APC) through a synaptic connection (the immune synapse) that subsequently controls T cell activation and function. This association recruits key actin regulatory proteins to the synapse, including Wiskott-Aldrich syndrome protein (WASP) and the small guanosine triphosphatase Cdc42, which ...
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Deacetylating Microtubules at the Immune Synapse

Science's STKE, 2004
T cell activation by antigen-presenting cells (APCs) involves formation of the immune synapse, a specialized junction characterized by supramolecular clusters of antigen receptors and other signaling molecules. Although the actin cytoskeleton has been implicated in this process, the role of microtubules in T cell activation is less well ...
openaire   +1 more source

Studying the Dynamics of TCR Internalization at the Immune Synapse

2017
Establishing a stable interaction between a T cell and an antigen presenting cell (APC) involves the formation of an immune synapse (IS). It is through this structure that the T cell can integrate all the signals provided by the APC. The IS also serves as a mechanism for TCR downregulation through internalization.
Enrique, Calleja, Balbino, Alarcón, Clara L, Oeste   +2 more
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Studying the T Cell-Astrocyte Immune Synapse

2017
In this chapter, we describe the technical details to visualize and analyze effector immunological synapses between T cells and astrocytes in the brain with high-resolution confocal imaging. This procedure is critical for the optimal and even penetration of labeling antibodies within the nerve tissue to obtain accurate staining and allow a uniform ...
George P, Cribaro, Elena, Saavedra-López, Paola V, Casanova, Laura, Rodríguez, Carlos, Barcia   +4 more
openaire   +2 more sources

The Immune Synapse

2023
openaire   +1 more source

SARS-CoV-2 Spike Protein Suppresses CTL-Mediated Killing by Inhibiting Immune Synapse Assembly

Journal of Experimental Medicine, 2023
Mario Milco D'Elios, Chiara Della Bella, Francesca Finetti   +2 more
exaly