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APC, T Cells, and the Immune Synapse
2009CD4(+) T cells engage different activating cells during their generation in the bone marrow and thymus and during their homeostasis and activation in the periphery. During these processes, T cells or their precursors establish a molecular platform for communication in the interface between the two cells that is called immune synapse (IS).
Reichardt, Peter +2 more
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Ultrastructure of Immune Synapses
2017The immunological synapse is a critical event for immune response development. The use of planar supported bilayers as surrogate antigen-presenting cells is a useful tool to study this phenomenon. Here we describe electron microscopy methods and approaches to expand our knowledge of the events taking place during the initial phases of T cell activation
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Analysis of the kinomic and immune cancer synapse in GBM
2021A deeper understanding of the signalling networks operating in vivo is needed to develop more physiologically relevant ex-vivo models and support the discovery of new therapeutics in human cancer. An example is human brain cancer where new therapeutics using essentially cancer cell models has failed to deliver therapeutic that work well in vivo.
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Dysfunctional Immune Synapses in T Cell Immunodeficiencies
2021Adaptive immune responses take place in the T cell area of secondary lymphoid organs, where, on encounter of antigen-presenting cells (APCs) bearing specific MHC-associated antigen, T lymphocytes assemble a highly organized intercellular junction, referred to as the immune synapse, on which T cell activation, proliferation, and differentiation ...
Capitani, N. +3 more
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Actin' Up in the Immune Synapse
Science Signaling, 2003A T cell engages an antigen presenting cell (APC) through a synaptic connection (the immune synapse) that subsequently controls T cell activation and function. This association recruits key actin regulatory proteins to the synapse, including Wiskott-Aldrich syndrome protein (WASP) and the small guanosine triphosphatase Cdc42, which ...
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Deacetylating Microtubules at the Immune Synapse
Science's STKE, 2004T cell activation by antigen-presenting cells (APCs) involves formation of the immune synapse, a specialized junction characterized by supramolecular clusters of antigen receptors and other signaling molecules. Although the actin cytoskeleton has been implicated in this process, the role of microtubules in T cell activation is less well ...
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Studying the T Cell-Astrocyte Immune Synapse
2017In this chapter, we describe the technical details to visualize and analyze effector immunological synapses between T cells and astrocytes in the brain with high-resolution confocal imaging. This procedure is critical for the optimal and even penetration of labeling antibodies within the nerve tissue to obtain accurate staining and allow a uniform ...
George P, Cribaro +4 more
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Studying the Dynamics of TCR Internalization at the Immune Synapse
2017Establishing a stable interaction between a T cell and an antigen presenting cell (APC) involves the formation of an immune synapse (IS). It is through this structure that the T cell can integrate all the signals provided by the APC. The IS also serves as a mechanism for TCR downregulation through internalization.
Enrique, Calleja +2 more
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