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Immune Tolerance Regulation Is Critical to Immune Homeostasis [PDF]
Journal of Immunology ResearchThe body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health.
Lei Han +4 more
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Approaches to Establishing Tolerance in Immune Mediated Diseases
Frontiers in Immunology, 2021 The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from
Michelle F. Huffaker +6 more
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The flawless immune tolerance of pregnancy [PDF]
Joint Bone Spine, 2021 International ...
Genebrier, Steve, Tarte, Karin
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Immune Tolerance in the Oral Mucosa [PDF]
International Journal of Molecular Sciences, 2021 The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanisms that enable this tolerance are not yet fully defined.
Hector F. Pelaez-Prestel +3 more
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Advancements in immune tolerance [PDF]
Advanced Drug Delivery Reviews, 2008 In recent years, considerable attention has been given to immune tolerance and its potential clinical applications for the treatment of cancers and autoimmune diseases, and the prevention of allo-graft rejection and graft-versus-host diseases. Advances in our understanding of the underlying mechanisms of establishment and maintenance of immune ...
Shu Hsia Chen +3 more
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Frontiers in Immunology, 2022 Immunotherapy for food-allergic patients has been effective in inducing desensitization in some populations, but long-term tolerance has remained an elusive target.
Carolyn H. Baloh +4 more
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A Breakdown of Immune Tolerance in the Cerebellum [PDF]
Brain Sciences, 2022 Cerebellar dysfunction can be associated with ataxia, dysarthria, dysmetria, nystagmus and cognitive deficits. While cerebellar dysfunction can be caused by vascular, traumatic, metabolic, genetic, inflammatory, infectious, and neoplastic events, the cerebellum is also a frequent target of autoimmune attacks. The underlying cause for this vulnerability
Christiane S. Hampe, Hiroshi Mitoma
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Immune Tolerance and Transplantation [PDF]
Seminars in Oncology, 2012 Successful allogeneic hematopoietic stem cell transplantation (HSCT) and solid organ transplantation require development of a degree of immune tolerance against allogeneic antigens. T lymphocytes play a critical role in allograft rejection, graft failure, and graft-versus-host disease (GVHD).
Marcel R.M. van den Brink +1 more
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Immune Tolerance of the Human Decidua [PDF]
Journal of Clinical Medicine, 2021 The endometrium is necessary for implantation, complete development of the placenta, and a successful pregnancy. The endometrium undergoes repeated cycles of proliferation, decidualization (differentiation), and shedding during each menstrual cycle.
Hiromi Murata +2 more
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Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
Nature Communications, 2023 Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao +12 more
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