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Regulatory T Cells and Immune Tolerance [PDF]
Cell, 2008 Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery.
S. Sakaguchi +3 more
semanticscholar +4 more sources
Immune Tolerance in the Oral Mucosa [PDF]
International Journal of Molecular Sciences, 2021 The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms.
Hector F. Pelaez-Prestel +3 more
semanticscholar +4 more sources
Immune Tolerance of the Human Decidua [PDF]
Journal of Clinical Medicine, 2021 The endometrium is necessary for implantation, complete development of the placenta, and a successful pregnancy. The endometrium undergoes repeated cycles of proliferation, decidualization (differentiation), and shedding during each menstrual cycle.
Hiromi Murata, Susumu Tanaka, H. Okada
semanticscholar +4 more sources
The Immune Tolerance Network: tolerance at the crossroads [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
Jeffrey A. Bluestone, Jeffrey Matthe
openalex +4 more sources
Influence of Innate Immunity on Immune Tolerance.
Acta Medica Academica, 2020 This review mainly focuses on the mechanisms of peripheral immune tolerance within the perspectives of innate immunity. Healthy immune response requires balanced interaction of the highly specialized elements of immunity within a harmony. Innate immunity
U. Kucuksezer +3 more
semanticscholar +4 more sources
Liver-Mediated Adaptive Immune Tolerance
Frontiers in Immunology, 2019 The liver is an immunologically tolerant organ that is uniquely equipped to limit hypersensitivity to food-derived antigens and bacterial products through the portal vein and can feasibly accept liver allografts.
Meijuan Zheng +2 more
doaj +2 more sources
Immune Tolerance Regulation Is Critical to Immune Homeostasis
Journal of Immunology ResearchThe body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health.
Lei Han +4 more
doaj +3 more sources
Approaches to Establishing Tolerance in Immune Mediated Diseases
Frontiers in Immunology, 2021 The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from
Michelle F. Huffaker +6 more
doaj +1 more source
Repetitive Antigen Responses of LDL-Reactive CD4+ T Cells Induce Tr1 Cell–Mediated Immune Tolerance
Arteriosclerosis, Thrombosis and Vascular Biology, 2023 BACKGROUND: Inflammation triggered by the deposition of LDL (low-density lipoprotein) in the arterial wall leads to the development of atherosclerosis.
R. Mailer +8 more
semanticscholar +1 more source
Bifidobacterium mechanisms of immune modulation and tolerance
Gut microbes, 2023 Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial pro-homeostatic and anti-inflammatory immunomodulatory properties.
Samuel J. Gavzy +5 more
semanticscholar +1 more source