Results 21 to 30 of about 288,299 (272)
Regulatory T Cells and Immune Tolerance [PDF]
Cell, 2008 Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery.
Shimon Sakaguchi +4 more
openaire +3 more sources
F1000Research, 2018 Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes.
William D. Coley +6 more
doaj +1 more source
Cytokine regulation of immune tolerance [PDF]
Burns & Trauma, 2014 The immune system provides defenses against invading pathogens while maintaining immune tolerance to self-antigens. This immune homeostasis is harmonized by the direct interactions between immune cells and the cytokine environment in which immune cells develop and function. Herein, we discuss three non-redundant paradigms by which cytokines maintain or
Jie Wu, Aini Xie, Wenhao Chen
openaire +3 more sources
F1000Research, 2018 Background: We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes.
William D. Coley +6 more
doaj +1 more source
Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr +7 more
doaj +1 more source
Effects of viral and cytokine delays on dynamics of autoimmunity [PDF]
Mathematics 6, 66 (2018), 2018 A major contribution to the onset and development of autoimmune disease is known to come from infections. An important practical problem is identifying the precise mechanism by which the breakdown of immune tolerance as a result of immune response to infection leads to autoimmunity. In this paper, we develop a mathematical model of immune response to a
arxiv +1 more source
miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes
Frontiers in Endocrinology, 2020 The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized.
Martin G. Scherm +4 more
doaj +1 more source
Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells [PDF]
PLoS Comput Biol 8(5): e1002526, 2012, 2012 The innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by macrophages are classic examples of the complex adaptation of innate immune cells.
arxiv +1 more source
Frontiers in Immunology, 2019 Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma +11 more
doaj +1 more source
CD4+CD25+ T regulatory cells in renal transplantation
Frontiers in Immunology, 2022 The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg represent &
Jason Cheung +15 more
doaj +1 more source