Results 31 to 40 of about 288,299 (272)
Clinical and Developmental Immunology, 2013 Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an
Corina Peña +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: The lack of knowledge of the progression mechanisms of glioblastoma (GB), the most aggressive brain tumor, contributes to the absence of successful therapeutic strategies.
María Luisa Molina +14 more
doaj +1 more source
Regulation of T Follicular Helper Cells in Islet Autoimmunity
Frontiers in Immunology, 2018 T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune ...
Isabelle Serr +3 more
doaj +1 more source
Frontiers in Immunology, 2022 RationalePrevious studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for ...
Kanika Kanchan +18 more
doaj +1 more source
Clocked Quantum-dot Cellular Automata Circuits Tolerate Unwanted External Electric Fields [PDF]
, 2022 Quantum-dot cellular automata (QCA) may provide low-power, general-purpose computing in the post-CMOS era. A molecular implementation of QCA features nanometer-scale devices and may support THz switching speeds at room-temperature. Here, we explore the ability of molecular QCA circuits to tolerate unwanted applied electric fields, which may come from a
arxiv +1 more source
Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression
Frontiers in Immunology, 2022 Myeloid-derived suppressor cells (MDSCs) are myeloid precursors that exert potent immunosuppressive properties in cancer. Despite the extensive knowledge on mechanisms implicated in mobilization, recruitment, and function of MDSCs, their therapeutic ...
Iosif Papafragkos +9 more
doaj +1 more source
Frontiers in Immunology, 2021 Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio +13 more
doaj +1 more source
Towards a quantitative theory of tolerance [PDF]
arXiv, 2023 A cornerstone of the classical view of tolerance is the elimination of self-reactive T cells during negative selection in the thymus. However, high-throughput T-cell receptor sequencing data has so far failed to detect substantial signatures of negative selection in the observed repertoires.
arxiv
A small PAM optimises target recognition in the CRISPR-Cas immune system [PDF]
arXiv, 2021 CRISPR-Cas is an adaptive immune mechanism that has been harnessed for a variety of genetic engineering applications: the Cas9 protein recognises a 2-5nt DNA motif, known as the PAM, and a programmable crRNA binds a target DNA sequence that is then cleaved.
arxiv
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Nature Communications, 2016 Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr +11 more
doaj +1 more source