Results 31 to 40 of about 329,007 (162)

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Emanuele Bosi, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori   +13 more
doaj   +1 more source

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies

Frontiers in Immunology, 2019
Rodent models of rheumatoid arthritis (RA) have been used over decades to study the immunopathogenesis of the disease and to explore intervention strategies.
Katina Schinnerling, Katina Schinnerling, Carlos Rosas, Lilian Soto, Lilian Soto, Ranjeny Thomas, Juan Carlos Aguillón   +6 more
doaj   +1 more source

Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

Frontiers in Immunology, 2021
The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and ...
Jin-Yu Sun, Rui Wu, Rui Wu, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji   +7 more
doaj   +1 more source

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity

Molecular Metabolism, 2019
Background: microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets.
Martin G. Scherm, Isabelle Serr, Klaus H. Kaestner, Carolin Daniel   +3 more
doaj   +1 more source

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Nature Communications, 2019
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel   +11 more
doaj   +1 more source

Immune tolerance induced by immune-homeostatic particles

Engineered Regeneration, 2021
Autoimmune diseases, induced by dysfunction of the adaptive immune system, are the common disease categories worldwide. Recently, regulatory T cells (Tregs) enhancing therapies have been demonstrated to treat autoimmune diseases, which could induce ...
Guopu Chen, Hui Zhang, Huan Wang, Fengyuan Wang   +3 more
doaj   +1 more source

IMMUNOLOGIC TOLERANCE AFTER SPECIFIC IMMUNIZATION [PDF]

The Journal of Experimental Medicine, 1964
Specific immunologic tolerance to bovine serum albumin (BSA) was induced in approximately one-half of the rabbits that had been primarily immunized and were prepared for a secondary antibody response to BSA. The state of tolerance lasted for several months in the majority of rabbits and was not easily terminated by immunization with human serum albumin
M M, DORNER, J W, UHR
openaire   +2 more sources

Distribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals

Biological Research
Background Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the “Shared Epitope” (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information
Miqueas Jaime, Lucero Toro, Constanza Varela-Villarroel, Darly Montano-Bruno, Bárbara Pesce, Daniela Schneider, Lilian Soto, Francisca Bozán, Óscar Neira, María C. Cuéllar-Gutiérrez, Consuelo Arroyo, Guido Rivera, Eduard Palou, Diego Catalán, Jaxaira Maggi, Juan C. Aguillón   +15 more
doaj   +1 more source

Cytokine regulation of immune tolerance [PDF]

Burns & Trauma, 2014
The immune system provides defenses against invading pathogens while maintaining immune tolerance to self-antigens. This immune homeostasis is harmonized by the direct interactions between immune cells and the cytokine environment in which immune cells develop and function. Herein, we discuss three non-redundant paradigms by which cytokines maintain or
Chen, Wenhao, Wu, Jie, Xie, Aini
openaire   +2 more sources

Short-term cold exposure supports human Treg induction in vivo

Molecular Metabolism, 2019
Objective: Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly prone ...
Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel   +9 more
doaj   +1 more source