Results 11 to 20 of about 1,132 (124)

Histopathological Association Between Chronic Endometritis and Adenomyosis: Clinical Findings and Risk Factors [PDF]

Reproductive Medicine and Biology
Purpose To investigate the histopathological association between chronic endometritis (CE) and adenomyosis, focusing on basal endometrial alterations and the potential involvement of tissue injury and repair (TIAR) mechanisms.
Batuhan Aslan, Cevriye Cansız Ersöz, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu   +7 more
doaj   +3 more sources

Clinical management of CMML-State of the art. [PDF]

Br J Haematol
Patients with chronic myelomonocytic leukaemia (CMML) typically present with clinical feature including splenomegaly, constitutional symptoms and autoimmune phenomena, as well as with pathological blood counts and biological features in the marrow. These characteristics may influence the assignment to prognostic categories such as the CPSSmol and also ...
Nachtkamp K, Schulz F, Gattermann N, Germing U.   +3 more
europepmc   +2 more sources

Morphological, immunohistochemical and molecular analysis of follicular dendritic cell sarcomas: L1CAM as a new diagnostic marker. [PDF]

Histopathology
Pathohistological analysis of FDCS revealed a morphological spectrum and led to the identification of the adhesion molecule L1CAM as a novel diagnostic immunomarker for FDCS. Sequencing identified NFKBIA as the most frequently altered gene, of note, exclusively in cases with a predominant epithelioid cytomorphology.
Schelbert S, Maurus K, Roth S, Ott G, Kurz KS, Mogler C, Wollenberg B, Linde J, Zamo A, Anagnostopoulos I, Gramlich S, Rosenwald A, Gerhard-Hartmann E.   +12 more
europepmc   +2 more sources

Activation of CD8⁺ T Cells in the Human Ex Vivo Lung Tumor Microenvironment Using Anti-CD3/CD28 and Nivolumab. [PDF]

Eur J Immunol
Patient heterogeneity remains a challenge in the treatment of lung cancer. Here, patient‐derived, ex vivo tumor lung slices originating from the tumor‐border are used to unravel microenvironment‐specific responses to immunotherapies. The focus lies on the impact of the native tumor microenvironment on CD8+ T cell activation after anti‐CD3/CD28 or anti ...
Bargmann T, Konzok S, Liguori R, Fuchs M, Sommer C, Schaudien D, Schob C, Halle S, Werlein C, Zardo P, Neubert L, Jonigk D, Fieguth HG, Ferrazzi F, Sewald K, Dehmel S, Braun A.   +16 more
europepmc   +2 more sources

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer [PDF]

Biomedicines, 2023
Background: Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses, and certain clinical and molecular markers have been studied as potential prognosticators of patient survival.
Dávid Fodor, Éva Pozsgai, Andrew V. Schally, Zoltán László, Éva Gömöri, Éva Szabó, László Rumi, Dorottya Lőcsei, Árpád Boronkai, Szabolcs Bellyei   +9 more
doaj   +2 more sources

Identifying the potential origin of mucin in primary cutaneous mucinoses—A retrospective study and analysis using histopathology and multiplex fluorescence staining

Journal of the European Academy of Dermatology and Venereology, Volume 37, Issue 7, Page 1302-1310, July 2023., 2023
Abstract Background Primary cutaneous mucinoses (PCM) are rare diseases characterized by dermal or follicular mucin deposits. Objectives A retrospective study characterizing PCM to compare dermal with follicular mucin to identify its potential origin on a single‐cell level.
S. Steinmann, C. Guillet, P. F. Cheng, M. P. Levesque, R. Dummer, I. Kolm, J. T. Maul   +6 more
wiley   +1 more source

Prevalence of Microorganisms in Atherosclerotic Plaques of Coronary Arteries: A Systematic Review and Meta‐Analysis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. In this systematic review and meta‐analysis, the existence of pathogens in atherosclerotic plaques of coronary arteries was investigated in coronary arteries diseases (CAD) patients. Methods. This study was designed and implemented up to 31 August 2020.
Iman Razeghian-Jahromi, Zahra Elyaspour, Mohammad Javad Zibaeenezhad, Soheil Hassanipour, Sandrina A. Heleno   +4 more
wiley   +1 more source

Application of mid‐infrared microscopic imaging for the diagnosis and classification of human lymphomas

Journal of Biophotonics, Volume 14, Issue 9, September 2021., 2021
Mid‐infrared microscopic (MIR) imaging is a spectroscopic technique that uses infrared radiation to image molecules of interest and can also be applied in thin tissue sections. To explore the benefits and challenges for lymphoma diagnosis and classification, we performed MIR imaging of human lymphomas.
Ella Willenbacher, Andrea Brunner, Bettina Zelger, Seraphin H. Unterberger, Roland Stalder, Christian W. Huck, Wolfgang Willenbacher, Johannes D. Pallua   +7 more
wiley   +1 more source

Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task

Journal of Neurochemistry, Volume 157, Issue 6, Page 2008-2023, June 2021., 2021
NAA synthase NAT8L and NAAG synthetase II (NAAGS‐II, encoded by the gene Rimkla) act together to synthesize the neuropeptide N‐acetylaspartylglutamate (NAAG), a cotransmitter at various synapses, a ligand of metabotropic glutamate receptor mGluR3 and a substrate of glutamate carboxypeptidase II (GCPII).
Ivonne Becker, Lihua Wang‐Eckhardt, Julia Lodder‐Gadaczek, Yong Wang, Agathe Grünewald, Matthias Eckhardt   +5 more
wiley   +1 more source

DMBT1 is upregulated in lung epithelial cells after hypoxia and changes surfactant ultrastructure

Pediatric Pulmonology, Volume 55, Issue 11, Page 2964-2969, November 2020., 2020
Abstract Background Hypoxia and asphyxia are known to induce surfactant inactivation in newborns. Deleted in Malignant Brain Tumors 1 (DMBT1) is an innate immunity protein with functions in epithelial differentiation and angiogenesis. It was detected in hyaline membranes of infants with respiratory distress syndrome.
Hanna Müller, Andreas Schmiedl, Christel Weiss, Maria Ai, Susan Jung, Marcus Renner   +5 more
wiley   +1 more source