Results 1 to 10 of about 2,498,524 (354)

Abstracts from the 2nd Annual MI4 Scientific Symposium on December 4, 2020

McGill Journal of Medicine, 2021
N ...
McGill Interdisciplinary Initiative in Infection and Immunity (MI4)
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Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry

STAR Protocols, 2022
Summary: With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative.
Stephanie Kucykowicz, Oliver E. Amin, Alice R. Burton, Leo Swadling, Nathalie M. Schmidt, Nekisa Zakeri, Jessica Davies, Gloryanne Aidoo-Micah, Kerstin A. Stegmann, Nicholas J. Easom, Anna Jeffery-Smith, Mala K. Maini, Laura J. Pallett   +12 more
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A case report describing the immune response of an infant with congenital heart disease and severe COVID-19

Communications Medicine, 2021
Wurzel et al. describe the kinetics of the immune response in relation to clinical and virological features in a 5-month old infant with congenital heart disease and severe COVID-19.
Danielle Wurzel, Melanie R. Neeland, Jeremy Anderson, Yara-Natalie Abo, Lien Anh Ha Do, Celeste M. Donato, Julie E. Bines, Zheng Quan Toh, Rachel A. Higgins, Sedi Jalali, Theresa Cole, Kanta Subbarao, Alissa McMinn, Kate Dohle, Gabrielle M. Haeusler, Sarah McNab, Annette Alafaci, Isabella Overmars, Vanessa Clifford, Lai-yang Lee, Andrew J. Daley, Jim Buttery, Penelope A. Bryant, David Burgner, Andrew Steer, Shidan Tosif, Igor E. Konstantinov, Trevor Duke, Paul V. Licciardi, Daniel G. Pellicci, Nigel W. Crawford   +30 more
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Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

Nature Communications, 2021
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini   +20 more
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The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Nature Communications, 2023
A gB/MF59 vaccine candidate for human cytomegalovirus (HCMV) provided partial protection in organ transplant patients. Here, the authors identify antibody responses in trial participants that target virally infected cells to control cell-to-cell spread ...
A. C. Gomes, I. A. Baraniak, A. Lankina, Z. Moulder, P. Holenya, C. Atkinson, G. Tang, T. Mahungu, F. Kern, P. D. Griffiths, M. B. Reeves   +10 more
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Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Nature Communications, 2022
Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires CD28 ...
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker   +14 more
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Comparison of antibody responses to SARS-CoV-2 variants in Australian children

Nature Communications, 2022
Despite a rise in COVID-19 cases among children, there is limited understanding of the antibody responses mounted, compared to in adults. In this work, authors compare seroconversion rates and antibody responses in unvaccinated Australian children across
Zheng Quan Toh, Nadia Mazarakis, Jill Nguyen, Rachel A. Higgins, Jeremy Anderson, Lien Anh Ha Do, David P. Burgner, Nigel Curtis, Andrew C. Steer, Kim Mulholland, Nigel W. Crawford, Shidan Tosif, Paul V. Licciardi   +12 more
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Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Nature Communications, 2022
Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a ...
Mariya Misheva, Konstantinos Kotzamanis, Luke C. Davies, Victoria J. Tyrrell, Patricia R. S. Rodrigues, Gloria A. Benavides, Christine Hinz, Robert C. Murphy, Paul Kennedy, Philip R. Taylor, Marcela Rosas, Simon A. Jones, James E. McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A. Czubala, Mark Gurney, Maceler Aldrovandi, Sven W. Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A. White, Valerie B. O’Donnell   +23 more
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Triiodothyronine (T3) Induces Limited Transcriptional and DNA Methylation Reprogramming in Human Monocytes

Biomedicines, 2022
Thyroid hormones have immunomodulatory roles, but their effects on the transcriptome and epigenome of innate immune cell types remain unexplored. In this study, we investigate the effects of triiodothyronine (T3) on the transcriptome and methylome of ...
Rebecca Shepherd, Bowon Kim, Richard Saffery, Boris Novakovic   +3 more
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Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma

Nature Communications, 2022
Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated ...
Nekisa Zakeri, Andrew Hall, Leo Swadling, Laura J. Pallett, Nathalie M. Schmidt, Mariana O. Diniz, Stephanie Kucykowicz, Oliver E. Amin, Amir Gander, Massimo Pinzani, Brian R. Davidson, Alberto Quaglia, Mala K. Maini   +12 more
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