Results 91 to 100 of about 449,551 (293)

The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation [PDF]

, 2012
Heterologous immunity is a mechanism by which immunological memory within an individual, developed in response to a previous infection, plays a role in the immune response to a subsequent unrelated infection.
Watkin, Levi B.
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity

, 2006
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations has led to the development of recombinant adenovirus (rAd) vectors derived from rare Ad serotypes as vaccine candidates for human immunodeficiency virus type ...
Thorner, Anna R., Lynch, Diana M., Denholtz, Matthew, Havenga, Menzo J. E., Lemckert, Angelique A. C., Goudsmit, Jaap, Barouch, Dan H., Ewald, Bonnie A.   +7 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model

Life Science Alliance
Repeated blood stage infections with the human malaria parasite, Plasmodium vivax , induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.
Nicanor Obaldía, Joao Luiz Da Silva Filho, Marlon Núñez, Katherine A Glass, Tate Oulton, Fiona Achcar, Grennady Wirjanata, Manoj Duraisingh, Philip Felgner, Kevin KA Tetteh, Zbynek Bozdech, Thomas D Otto, Matthias Marti   +12 more
doaj   +1 more source

BCG vaccination: a role for vitamin D? [PDF]

, 2011
BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Hazel M. Dockrell, Rose Blitz, Branson Keith, Maeve K. Lalor, Blitz, R, Lalor Maeve K., Fine Paul E., Branson, K, Hazel M Dockrell, Maeve K Lalor, Floyd Sian, Fine, PE, Rosemary E Weir, Weir, RE, Gorak-Stolinska, Patricia, Rosemary E. Weir, Sian Floyd, Fine, Paul E, Lalor, MK, Floyd, Sian, Paul E. Fine, Blitz, Rose, Dockrell Hazel M., Weir, Rosemary E, Keith Branson, Paul E Fine, Weir Rosemary E., Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Branson, Keith, Patricia Gorak-Stolinska, Floyd, S, Blitz Rose   +35 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Homologous MVA and heterologous DREP/MVA vaccine regimens induce robust and durable immune responses against SARS-CoV-2

Scientific Reports
Despite the success of current COVID-19 vaccines, the immunity they generate wanes over time, requiring periodic boosters. The limited durability of memory responses, particularly from mRNA vaccines, remains a major challenge for achieving long-term ...
Patricia Pérez, Gloria Esteso, María A. Noriega, Laura Perez Vidakovics, Peter Liljeström, Gerald M. McInerney, Mariano Esteban, Juan García-Arriaza   +7 more
doaj   +1 more source

Decade-Long Sustained Cellular Immunity Induced by Sequential and Repeated Vaccination with Four Heterologous HIV Vaccines in Rhesus Macaques

Vaccines
Background/Objectives: Developing durable cellular immunity remains a critical challenge for HIV vaccine development. Methods: We evaluated a sequential and repeated heterologous prime–boost vaccination regimen using four distinct vector-based vaccines ...
Xiaozhou He, Danying Chen, Qi Ma, Yanzhe Hao, Hongxia Li, Xiaoguang Zhang, Yuxi Cao, Xia Feng   +7 more
doaj   +1 more source