Results 71 to 80 of about 49,620 (199)

Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells [PDF]

, 2019
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly,
James D. Brien, Amelia K. Pinto, Mariah Hassert   +2 more
core   +1 more source

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

Frontiers in Immunology
Heterologous prime–boost vaccination has emerged as a promising approach to enhance immune responses by combining vaccines with complementary mechanisms of antigen delivery and immune activation.
Alena Reguzova, Verena Haug, Verena Haug, Carina Metz, Carina Metz, Melanie Müller, Madeleine Fandrich, Alex Dulovic, Ralf Amann   +8 more
doaj   +1 more source

Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination

, 2009
A heterologous prime-boost strategy using plasmid DNA, followed by replication-defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4(+) and CD8(+) T-cell-mediated protective immunity against intracellular pathogens.
Machado, Alexandre V., Filipe A. Haolla, Rodrigues, Mauricio M., Bruna C. G. de Alencar, Gazzinelli, Ricardo T., Persechini, Pedro M., Silverio, Jaline C., Lannes-Vieira, Joseli, Oscar Bruna-Romero, Mauricio M. Rodrigues, Bruna-Romero, Oscar, Haolla, Filipe A., Rodrigues, Mauricio M. [UNIFESP], Joseli Lannes-Vieira, Haolla, Filipe A. [UNIFESP], Ricardo T. Gazzinelli, Gabriel de Oliveira, Oliveira, Gabriel de, Alencar, Bruna C. G. de, Jaline C. Silverio, Alencar, Bruna C. G. de [UNIFESP], Alexandre V. Machado, Pedro M. Persechini   +22 more
core   +1 more source

T and B cell responses in different immunization scenarios for COVID-19: a narrative review

Frontiers in Immunology
Vaccines against COVID-19 have high efficacy and low rates of adverse events. However, none of the available vaccines provide sterilizing immunity, and reinfections remain possible.
Eva Piano Mortari, Francesca Ferrucci, Irini Zografaki, Rita Carsetti, Luciano Pacelli   +4 more
doaj   +1 more source

Induction and in Vitro demonstration of cellular immunity to DNA and RNA viruses in guinea-pigs [PDF]

, 1975
Guinea-pigs were immunized with different cells infected with vaccinia virus, herpes simplex virus type 1, herpesvirus saimiri, and the virus of vesicular stomatitis. Development of cellular immunity against these viruses was observed with transformation
U. Koszinowski, Koszinowski, Ulrich H., G. Bandlow, Bandlow, G.   +3 more
core  

Studies on heterologous immunity in schistosomiasis. 4. Heterologous schistosome immunity in cattle.

Bulletin of the World Health Organization, 1970
Previous studies have shown that when mice and monkeys are infected with bovine schistosomes they develop a considerable degree of heterologous immunity against subsequent challenge with Schistosoma mansoni. The present report describes a study on the reverse effect in which calves were first exposed to cercariae of S.
M F, Hussein, A A, Saeed, G S, Nelson
openaire   +1 more source

Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species. [PDF]

PLoS Pathogens, 2010
A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new
Lisa E Hensley, Sabue Mulangu, Clement Asiedu, Joshua Johnson, Anna N Honko, Daphne Stanley, Giulia Fabozzi, Stuart T Nichol, Thomas G Ksiazek, Pierre E Rollin, Victoria Wahl-Jensen, Michael Bailey, Peter B Jahrling, Mario Roederer, Richard A Koup, Nancy J Sullivan   +15 more
doaj   +1 more source

Studies on heterologous immunity in schistosomiasis. I. Heterologous schistosome immunity in mice.

Bulletin of the World Health Organization, 1968
Epidemiological and experimental studies indicate that heterologous immunity resulting from exposure to bovine and other animal schistosomes might be of some importance in determining the relative severity of schistosome infection in man in different parts of the world.
G S, Nelson, M A, Amin, M F, Saoud, C, Teesdale   +3 more
openaire   +1 more source

Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity

, 2006
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations has led to the development of recombinant adenovirus (rAd) vectors derived from rare Ad serotypes as vaccine candidates for human immunodeficiency virus type ...
Thorner, Anna R., Lynch, Diana M., Denholtz, Matthew, Havenga, Menzo J. E., Lemckert, Angelique A. C., Goudsmit, Jaap, Barouch, Dan H., Ewald, Bonnie A.   +7 more
core   +1 more source

Studies on heterologous immunity in schistosomiasis. 5. Heterologous schistosome immunity in sheep.

Bulletin of the World Health Organization, 1973
Previous studies have shown that when cattle are exposed to cercariae of Schistosoma mansoni they develop considerable resistance to subsequent challenge with S. mattheei. The present study showed that when sheep are immunized with S. mansoni cercariae they too develop a marked resistance to subsequent challenge with S. mattheei.
J M, Preston, G S, Nelson, A A, Saeed
openaire   +1 more source