Results 61 to 70 of about 49,620 (199)

Heterologous immunity provides a potent barrier to transplantation tolerance [PDF]

Journal of Clinical Investigation, 2003
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We hypothesized that a critical distinction between specific pathogen-free mice and nonhuman primates or human patients is their acquired immune history. Here, we show
Andrew B, Adams, Matthew A, Williams, Thomas R, Jones, Nozomu, Shirasugi, Megan M, Durham, Susan M, Kaech, E John, Wherry, Thandi, Onami, J Gibson, Lanier, Kenneth E, Kokko, Thomas C, Pearson, Rafi, Ahmed, Christian P, Larsen   +12 more
openaire   +2 more sources

Evaluation of non-reciprocal heterologous immunity between unrelated viruses

, 2015
Heterologous immunity refers to the phenomenon whereby a history of an immune response against one pathogen can provide a level of immunity to a second unrelated pathogen.
Selin, Liisa K., Raymond M. Welsh, Welsh, Raymond M., Jenny W. Che, Che, Jenny W., Liisa K. Selin   +5 more
core   +1 more source

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA [PDF]

, 2019
Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies.
John H. Adams, Mitran, Catherine J., Barakat, Khaled, Lima, Barbara AS, Adams, John H, Salanti, Ali, Ganesan, Aravindhan, Sedami Gnidehou, Amanda E. Maestre, Good, Michael F, Kano, Flora S., Barbara A. S. Lima, Flora S. Kano, Ntumngia, Francis, Lima, Barbara A.S., Francis Ntumngia, Khaled Barakat, Carvalho, Luzia H, Adams, John H., Banman, Shanna, Mbonye, Anthony K., Anthony K. Mbonye, Angie Mena, Mitran, Catherine J, Yanow, Stephanie K., Aravindhan Ganesan, Hazel Lugo, Mena, Angie, Good, Michael F., Kano, Flora S, Mbonye, Anthony K, Carvalho, Luzia H., Eliana Arango, Gnidehou, Sedami, Lugo, Hazel, Ali Salanti, Stephanie K. Yanow, Catherine J. Mitran, Michael F. Good, Luzia H. Carvalho, Yanow, Stephanie K, Maestre, Amanda E., Maestre, Amanda E, Arango, Eliana, Shanna Banman   +44 more
core   +1 more source

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science
With the ever‐present threat of pandemics, it is imperative vaccine technologies eliciting broad and durable immunity to high‐risk pathogens are developed. Yet, current annual influenza vaccines, for example, fail to provide robust immunity against the 3–
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
doaj   +1 more source

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Vaccines
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use.
Whitney C. Weber, Takeshi F. Andoh, Craig N. Kreklywich, Zachary J. Streblow, Michael Denton, Magdalene M. Streblow, John M. Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T. Curiel, Nicole N. Haese, Daniel N. Streblow   +12 more
doaj   +1 more source

Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation [PDF]

Autoimmunity, 2011
The relationship between biological research and mathematical modeling is complex, critical, and vital. In this review, we summarize the results of the collaboration between two laboratories, exploring the interaction between mathematical modeling and wet-lab immunology.
Calcagno, Claudia, Puzone, Roberto, Pearson, Yanthe E., Cheng, Yiming, Ghersi, Dario, Selin, Liisa K., Welsh, Raymond M., Celada, Franco   +7 more
openaire   +3 more sources

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Todryk, Stephen M., Plebanski Magdalena, Bejon, P, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Urban, B, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Flanagan, KL, Hill, AV, Philip Bejon, Bejon, Philip, Marsh Kevin, Marsh, K, Mwangi, T, Mwangi, Tabitha, Flanagan, Katie, Hill, Adrian V. S., Bejon Philip, Plebanski, M, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin, Todryk, SM, Flanagan, Katie L.   +37 more
core   +1 more source

The two faces of heterologous immunity: protection or immunopathology

Journal of Leukocyte Biology, 2013
ABSTRACTImmunity to previously encountered viruses can alter responses to unrelated pathogens. This phenomenon, which is known as heterologous immunity, has been well established in animal model systems. Heterologous immunity appears to be relatively common and may be beneficial by boosting protective responses.
Shalini, Sharma, Paul G, Thomas
openaire   +3 more sources

BCG vaccination: a role for vitamin D? [PDF]

, 2011
BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis.
Hazel M. Dockrell, Rose Blitz, Branson Keith, Maeve K. Lalor, Blitz, R, Lalor Maeve K., Fine Paul E., Branson, K, Hazel M Dockrell, Maeve K Lalor, Floyd Sian, Fine, PE, Rosemary E Weir, Weir, RE, Gorak-Stolinska, Patricia, Rosemary E. Weir, Sian Floyd, Fine, Paul E, Lalor, MK, Floyd, Sian, Paul E. Fine, Blitz, Rose, Dockrell Hazel M., Weir, Rosemary E, Keith Branson, Paul E Fine, Weir Rosemary E., Gorak-Stolinska, P, Dockrell, HM, Gorak-Stolinska Patricia, Lalor, Maeve K, Dockrell, Hazel M, Branson, Keith, Patricia Gorak-Stolinska, Floyd, S, Blitz Rose   +35 more
core   +1 more source

Suppression of heterologous immunity by Nematospiroides dubius antigens in vitro [PDF]

International Journal for Parasitology, 1989
The direct effect of the soluble antigens in the homogenate of adult Nematospiroides dubius (AH) on spleen cells from uninfected NIH mice was investigated using a Mishell-Dutton culture system. Parasite antigens were shown to reduce the plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in a dose-dependent manner in vitro.
Crawford, C.R., Behnke, Jerzy M., Pritchard, D.I.   +2 more
openaire   +3 more sources