Results 51 to 60 of about 49,620 (199)

Pathological Features of Heterologous Immunity Are Regulated by the Private Specificities of the Immune Repertoire [PDF]

The American Journal of Pathology, 2010
Heterologous immunity associated with cross-reactive T-cell responses is proposed to contribute to variations among individuals in the pathogenesis of human viral infections. In genetically identical mice with similar infection histories, marked variations in the magnitude and specificities of T-cell responses under conditions of heterologous immunity ...
Siwei, Nie, Sue-Jane, Lin, Sung-kwon, Kim, Raymond M, Welsh, Liisa K, Selin   +4 more
openaire   +2 more sources

Immune mechanisms mediating the heterologous effects of BCG vaccination: a systematic review

Frontiers in Immunology
IntroductionBCG vaccination can have heterologous or non-specific effects (NSE) that confer resistance against pathogens other than its target Mycobacterium tuberculosis, but the underlying mechanisms are not fully understood.MethodsWe conducted a ...
Louis Torracinta, Nino Gogichadze, Rachel Tanner   +2 more
doaj   +1 more source

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

mBio, 2015
The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of influenza vaccines for use in epidemics and pandemics.
Brendon Y. Chua, Chinn Yi Wong, Edin J. Mifsud, Kathryn M. Edenborough, Toshiki Sekiya, Amabel C. L. Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J. Turner, Peter C. Doherty, Anne Kelso, Lorena E. Brown, David C. Jackson   +13 more
doaj   +1 more source

Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets

npj Vaccines, 2022
The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity.
Selina Khan, Nadine C. Salisch, Ana Izquierdo Gil, Satish Boedhoe, Karin Feddes-de Boer, Jan Serroyen, Hanneke Schuitemaker, Roland C. Zahn   +7 more
doaj   +1 more source

Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity

, 2005
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 and other ...
Lynch, Diana M., Truitt, Diana M., Havenga, Menzo J. E., Lemckert, Angelique A. C., Barouch, Dan H., Nanda, Anjali, Ewald, Bonnie A., Sumida, Shawn M., Holterman, Lennart, Vogels, Ronald, Goudsmit, Jaap, Lifton, Michelle A., Gorgone, Darci A.   +12 more
core   +1 more source

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity [PDF]

, 2014
International audienceWe have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 ...
Preijers, Frank, van Loenhout, Joke, van Crevel, Reinout, Xavier, Ramnik, Joosten, Leo, Netea, Mihai, G., Jacobs, Cor, Aaby, Peter, Kleinnijenhuis, Johanneke, Benn, Christine Stabell, van Der Meer, Jos, W. M., Quintin, Jessica   +11 more
core   +2 more sources

MHC basis of T cell-dependent heterologous immunity to arenaviruses

, 2014
Having a history of infection with one pathogen may sometimes provide a level of T cell-dependent protective heterologous immunity to another pathogen.
Raymond M. Welsh, Welsh, Raymond M., Hatfield, Steven D., Keith A. Daniels, Steven D. Hatfield, Brehm, Michael A., Daniels, Keith A., Michael A. Brehm   +7 more
core   +1 more source

Heterologous immunity meets tissue-specific training [PDF]

Nature Reviews Immunology, 2016
Tracy Hussell describes a 2003 study by Chen et al. that pioneered the concept of heterologous immunity.
openaire   +2 more sources

Cross-Protective Immunity against Heterologous Streptococcus pneumoniae [PDF]

Infection and Immunity, 2012
Chimalapati et al. recently reported that infection with conditionally virulent Streptococcus pneumoniae Δ pab strains (containing a deletion of the gene encoding para -aminobenzoic acid synthetase) induced an effective antibody response to conserved protein antigens of S. pneumoniae ([1][1]).
Leen, Moens, Greet, Wuyts, Jan, Verhaegen, Xavier, Bossuyt   +3 more
openaire   +2 more sources

Exploring heterologous prime-boost vaccination approaches to enhance influenza control in pigs

Veterinary Research, 2020
Influenza A viruses evolve rapidly to escape host immunity. In swine, this viral evolution has resulted in the emergence of multiple H1 and H3 influenza A virus (IAV) lineages in the United States (US) pig populations.
Chong Li, Marie R. Culhane, Maxim Cheeran, Lucina Galina Pantoja, Micah L. Jansen, Deborah Amodie, Martha A. Mellencamp, Montserrat Torremorell   +7 more
doaj   +1 more source