Results 51 to 60 of about 449,551 (293)

Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity

Frontiers in Immunology, 2023
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines.
Larissa Henze, Larissa Henze, Julian Braun, Julian Braun, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Karsten Jürchott, Karsten Jürchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Maike Mangold, Manuela Dingeldey, Manuela Dingeldey, Beate Kruse, Beate Kruse, Pavlo Holenya, Norbert Mages, Norbert Mages, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Florian Klein, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Lucie Loyal, Andreas Thiel, Andreas Thiel   +36 more
doaj   +1 more source

Asymptomatic Plasmodium falciparum infections may not be shortened by acquired immunity [PDF]

, 2015
The duration of untreated Plasmodium falciparum infections is a defining characteristic of the parasite's biology. It is not clear whether naturally acquired immunity (NAI) can shorten infections, despite the potential implications for malaria control ...
Maire, Nicolas, Ingrid Felger, Michael T Bretscher, Tom Smith, Seth Owusu-Agyei, Owusu-Agyei, Seth, Nicolas Maire, Felger, Ingrid, Bretscher, Michael T, Smith, Tom, Bretscher, Michael T.   +10 more
core   +1 more source

Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity

, 2005
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 and other ...
Lynch, Diana M., Truitt, Diana M., Havenga, Menzo J. E., Lemckert, Angelique A. C., Barouch, Dan H., Nanda, Anjali, Ewald, Bonnie A., Sumida, Shawn M., Holterman, Lennart, Vogels, Ronald, Goudsmit, Jaap, Lifton, Michelle A., Gorgone, Darci A.   +12 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Immune mechanisms mediating the heterologous effects of BCG vaccination: a systematic review

Frontiers in Immunology
IntroductionBCG vaccination can have heterologous or non-specific effects (NSE) that confer resistance against pathogens other than its target Mycobacterium tuberculosis, but the underlying mechanisms are not fully understood.MethodsWe conducted a ...
Louis Torracinta, Nino Gogichadze, Rachel Tanner   +2 more
doaj   +1 more source

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

mBio, 2015
The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of influenza vaccines for use in epidemics and pandemics.
Brendon Y. Chua, Chinn Yi Wong, Edin J. Mifsud, Kathryn M. Edenborough, Toshiki Sekiya, Amabel C. L. Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J. Turner, Peter C. Doherty, Anne Kelso, Lorena E. Brown, David C. Jackson   +13 more
doaj   +1 more source

Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets

npj Vaccines, 2022
The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity.
Selina Khan, Nadine C. Salisch, Ana Izquierdo Gil, Satish Boedhoe, Karin Feddes-de Boer, Jan Serroyen, Hanneke Schuitemaker, Roland C. Zahn   +7 more
doaj   +1 more source

Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination [PDF]

, 2009
A heterologous prime-boost strategy using plasmid DNA, followed by replication-defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4(+) and CD8(+) T-cell-mediated protective immunity against intracellular pathogens.
Machado, Alexandre V., Filipe A. Haolla, Rodrigues, Mauricio M., Bruna C. G. de Alencar, Gazzinelli, Ricardo T., Persechini, Pedro M., Silverio, Jaline C., Lannes-Vieira, Joseli, Oscar Bruna-Romero, Mauricio M. Rodrigues, Bruna-Romero, Oscar, Haolla, Filipe A., Rodrigues, Mauricio M. [UNIFESP], Joseli Lannes-Vieira, Haolla, Filipe A. [UNIFESP], Ricardo T. Gazzinelli, Gabriel de Oliveira, Oliveira, Gabriel de, Alencar, Bruna C. G. de, Jaline C. Silverio, Alencar, Bruna C. G. de [UNIFESP], Alexandre V. Machado, Pedro M. Persechini   +22 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source