Results 111 to 120 of about 449,551 (293)

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Studies on heterologous immunity in schistosomiasis. 2. Heterologous schistosome immunity in rhesus monkeys.

Bulletin of the World Health Organization, 1968
Previous studies on heterologous immunity in mice have indicated that Schistosoma bovis and S. mattheei could be used to limit the severity of infection resulting from subsequent challenge by S. mansoni. These observations have now been extended to study the immunizing effect in rhesus monkeys of both S. mattheei and S.
M A, Amin, G S, Nelson, M F, Soud
openaire   +1 more source

Immune Response of Congenitally Thymusless Mice to Heterologous Erythrocytes

Experimental Biology and Medicine, 1972
SummaryHemagglutinin and hemolysin production by congenitally thymusless (“nude”) mice in response to intraperitoneal injection of 107, 108, 109, or 1010 sheep erythrocytes (SE) was significantly lower than in normal littermate controls. The plaque-forming cell response of nudes was also impaired.
Reed, N D, Jutila, J W
openaire   +2 more sources

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Effects of Grafting on the Structure and Function of Coffee Rhizosphere Microbiome

Agriculture
Heterologous double-root grafting represents an effective strategy to mitigate challenges associated with continuous coffee cropping and reduce soil-borne diseases. However, its specific regulatory mechanism remains unclear. Therefore, a field experiment
Yan Sun, Lin Yan, Ang Zhang, Jianfeng Yang, Qingyun Zhao, Xingjun Lin, Zixiao Zhang, Lifang Huang, Xiao Wang, Xiaoyang Wang   +9 more
doaj   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA [PDF]

, 2019
Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies.
John H. Adams, Mitran, Catherine J., Barakat, Khaled, Lima, Barbara AS, Adams, John H, Salanti, Ali, Ganesan, Aravindhan, Sedami Gnidehou, Amanda E. Maestre, Good, Michael F, Kano, Flora S., Barbara A. S. Lima, Flora S. Kano, Ntumngia, Francis, Lima, Barbara A.S., Francis Ntumngia, Khaled Barakat, Carvalho, Luzia H, Adams, John H., Banman, Shanna, Mbonye, Anthony K., Anthony K. Mbonye, Angie Mena, Mitran, Catherine J, Yanow, Stephanie K., Aravindhan Ganesan, Hazel Lugo, Mena, Angie, Good, Michael F., Kano, Flora S, Mbonye, Anthony K, Carvalho, Luzia H., Eliana Arango, Gnidehou, Sedami, Lugo, Hazel, Ali Salanti, Stephanie K. Yanow, Catherine J. Mitran, Michael F. Good, Luzia H. Carvalho, Yanow, Stephanie K, Maestre, Amanda E., Maestre, Amanda E, Arango, Eliana, Shanna Banman   +44 more
core   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Antibody Response after Homologous and Heterologous Prime–Boost COVID-19 Vaccination in a Bangladeshi Residential University Cohort

Vaccines
COVID-19 vaccination strategies, including heterologous prime–boost regimens and additional booster doses, aim to optimize immune responses. However, seroepidemiological studies on immune responses to different COVID-19 vaccine types and schedules remain
Nihad Adnan, Md. Ahsanul Haq, Salma Akter, S. M. Shafiul Alam Sajal, Md. Fokhrul Islam, Taslin Jahan Mou, Mohd. Raeed Jamiruddin, Fatema Tuz Jubyda, Md. Salequl Islam, Jamsheda Ferdous Tuli, Syeda Moriam Liza, Sharif Hossain, Zinia Islam, Sohel Ahmed, Shahad Saif Khandker, Rubel Hossain, Md. Firoz Ahmed, Mohib Ullah Khondoker, Nafisa Azmuda, Md. Anowar Khasru Parvez   +19 more
doaj   +1 more source