Results 121 to 130 of about 84,619 (287)

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia, Hallström, Teresia, Skerka, Christine, Wallich, Reinhard, Stevenson, Brian, Zipfel, Peter F., Kraiczy, Peter   +6 more
core   +3 more sources

Evaluation of non-reciprocal heterologous immunity between unrelated viruses

Virology, 2015
Heterologous immunity refers to the phenomenon whereby a history of an immune response against one pathogen can provide a level of immunity to a second unrelated pathogen. Previous investigations have shown that heterologous immunity is not necessarily reciprocal, such as in the case of vaccinia virus (VACV).
Che, Jenny W., Selin, Liisa K., Welsh, Raymond M.   +2 more
openaire   +2 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection

Nature Communications
Clinical immunity to malaria can lead to asymptomatic infection, but the underlying mechanisms remain unclear. To examine the development of clinical immunity, we conducted a multi-cohort, repeat controlled human malaria infection (CHMI) study with ...
Mimi M. Hou, Adam C. Harding, Natalie M. Barber, Prasun Kundu, Florian A. Bach, Jo Salkeld, Yrene Themistocleous, Nicola M. Greenwood, Jee-Sun Cho, Jordan R. Barrett, Fay L. Nugent, Thomas A. Rawlinson, Susanne H. Hodgson, Baktash Khozoee, Dylan J. Mac Lochlainn, Rachel E. Cowan, Ian D. Poulton, Megan Baker, Lucy Kingham, Celia H. Mitton, Abigail Platt, Raquel Lopez Ramon, Fernando Ramos Lopez, Merin Thomas, Katherine Skinner, Doris Quinkert, Dimitra Pipini, Amelia M. Lias, Martino Bardelli, Nick J. Edwards, Francesca R. Donnellan, Sumi Biswas, Julian C. Rayner, Carolyn M. Nielsen, Sarah E. Silk, Simon J. Draper, Wiebke Nahrendorf, Philip J. Spence, Angela M. Minassian   +38 more
doaj   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Pre-existing YFV-17D immunity mediates T cell cross-protection against dengue virus serotype 2 infection in mice

Communications Biology
Widespread yellow fever virus (YFV) immunity in Sub-Saharan Africa may mitigate orthoflavivirus outbreaks. Here, we investigate whether pre-existing YFV-17D immunity confers cross-protection against dengue virus serotype 2 (DENV-2) infection in a murine ...
Prince Baffour Tonto, Sebastian Gallon, Reem Alatrash, Yifeng Ding, Wei-Kung Wang, Bobby Brooke Herrera   +5 more
doaj   +1 more source

Immune Response of Congenitally Thymusless Mice to Heterologous Erythrocytes

Experimental Biology and Medicine, 1972
SummaryHemagglutinin and hemolysin production by congenitally thymusless (“nude”) mice in response to intraperitoneal injection of 107, 108, 109, or 1010 sheep erythrocytes (SE) was significantly lower than in normal littermate controls. The plaque-forming cell response of nudes was also impaired.
Reed, N D, Jutila, J W
openaire   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Humoral and cellular immune durability of different COVID-19 vaccine platforms following homologous/heterologous boosters: one-year post vaccination

Frontiers in Immunology
IntroductionThe durability of Hybrid immunity induced by natural infection and/or COVID-19 vaccines and evidence supporting further booster vaccination are crucial factors for pandemic response, yet remain poorly understood.MethodsWe measured the ...
Maaweya Awadalla, Halah Z. AlRawi, Rahaf A. Henawi, Fawziya Barnawi, Haitham Alkadi, Ahmed Alyami, Ammar Alsughayir, Alyazeed S. Alsaif, Ayman Mubarak, Wael Alturaiki, Bandar Alosaimi   +10 more
doaj   +1 more source