Results 131 to 140 of about 449,551 (293)

Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation

, 2009
By examining adoptively transferred CSFE-labeled lymphocytic choriomeningitis virus (LCMV)-immune donor T cells in Thy-1 congenic hosts inoculated with viruses or with the cytokine inducer poly(I:C), strikingly different responses of bona fide memory T ...
Selin, Liisa K., Welsh, Raymond M., Kim, Sung-Kwon, Brehm, Michael A.   +3 more
core   +1 more source

Exosome‐mimetic vesicle‐encapsulated multi‐responsive antibacterial hydrogel core‐shell microneedle patch promotes scarless healing of infected wounds

BMEMat, EarlyView.
The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang, Huihui Zhang, Lianglong Chen, Zhangfeifan Yang, Sai Cao, Yufang He, Xiaoyang Liu, Siew Yee Wong, Xu Li, Hai Zhou, Ziyan Li, Zijun Zheng, Lei Yang   +12 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Frontiers in Immunology
An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants.
Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Dennis Christensen, Gabriel Kristian Pedersen, Thorunn A. Olafsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson, Stefania P. Bjarnarson   +11 more
doaj   +1 more source

NONSPECIFIC IMMUNITY BY HETEROLOGOUS VACCINATION [PDF]

American Journal of Public Health and the Nations Health, 1933
openaire   +2 more sources

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Experimental cerebral malaria develops independently of caspase recruitment domain-containing protein 9 signaling.

, 2011
The outcome of infection depends on multiple layers of immune regulation, with innate immunity playing a decisive role in shaping protection or pathogenic sequelae of acquired immunity.
Jan Burgold, Hafalla, J.C., Kai Matuschewski, Julius Clemence R. Hafalla, Gross, Olaf, Jürgen Ruland, Stefan H. E. Kaufmann, Kaufmann, Stefan H. E., Olaf Gross, Hafalla, Julius Clemence R., Gross, O., Matuschewski, K., Matuschewski, Kai, Ruland, Jürgen, Kaufmann, Stefan HE, Ruland, J., Burgold, Jan, Hafalla, Julius Clemence R, Dorhoi, Anca, Burgold, J., Anca Dorhoi, Dorhoi, A., Kaufmann, S.H., Hafalla, JC;Burgold, J;Dorhoi, A;Gross, O;Ruland, J;Kaufmann, SH;Matuschewski, K   +23 more
core   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Broadening SARS-CoV-2 Immunity by Combining ORFV and Protein-Based Vaccines

Vaccines
Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection.
Alena Reguzova, Melanie Müller, Madeleine Fandrich, Alex Dulovic, Ralf Amann   +4 more
doaj   +1 more source

The Global Patent Landscape of Mushroom‐Derived Functional Foods: Current Status, Future Perspectives, and Artificial Intelligence–Driven Exploration

Food Safety and Health, EarlyView.
The global patent landscape of mushroom‐derived functional food was widely analyzed, and AI‐integrated approaches realizing cost‐effective and reliable exploration of functional foods derived from mushrooms were explored. ABSTRACT Global health concerns and the increasing demand for nourishment have collectively driven the rising demand for functional ...
Xihong Zhao, Linhuizi Xiang, Dongmei Liu, Shoucheng Qin, Yue Chen, Xueyan Sun   +5 more
wiley   +1 more source