Results 131 to 140 of about 84,619 (287)

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

Pediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou, Christopher L.‐H. Huang, Ying Yang, Yanmin Zhang   +3 more
wiley   +1 more source

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Frontiers in Immunology
An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants.
Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Dennis Christensen, Gabriel Kristian Pedersen, Thorunn A. Olafsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson, Stefania P. Bjarnarson   +11 more
doaj   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

The relationship of site to transplantability [PDF]

, 1963
Thesis (M.A.)--Boston ...
Anderson, Leonard L.
core  

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

VIEW, EarlyView.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng, Tengfei Ke, Hongjin Wang, Hong Huang, Ying Zhang, Guanghai Fei, Chengde Liao, Haiyan Yang   +7 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Art v 1 and Amb a 4 Co‐Sensitization Identifies Italian Patients at Risk for Mugwort‐Celery‐Spice Syndrome

Allergy, EarlyView.
Three molecular profiles identified among Art v 1/Amb a 4‐sensitized patients: Art v 1 monosensitization, Amb a 4 monosensitization, and dual sensitization to both allergens. Art v 1 monosensitization was predominantly associated with allergic rhinitis, reflecting a classical airborne allergy pattern.
Enrico Scala, Gabriella Cusa, Valeria Villella, Damiano Abeni, Mauro Giani, Emma Cristina Guerra, Maria Locanto, Giorgia Meneguzzi, Lia Pirrotta, Donato Quaratino, Alessandra Zaffiro, Elisabetta Caprini, Maria Barrale, Ignazio Brusca, Valerio Pravettoni, Lorenzo Cecchi, Danilo Villalta, Martina Aumayr, Irene Mittermann, Christian Lupinek, Riccardo Asero   +20 more
wiley   +1 more source

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward

Allergy, EarlyView.
ABSTRACT The oral food challenge (OFC) has long been the reference standard for food allergy diagnosis, as well as to confirm natural development of oral tolerance. The utilization of OFCs has significantly broadened from its role in defining disease to defining participant eligibility, individual allergen reactivity thresholds and treatment outcomes ...
Edwin H. Kim, J. Andrew Bird, Helen A. Brough, David M. Fleischer, Stacie M. Jones, Ildiko Kun, Wayne Shreffler, Claire Van Eenwyk, Brian P. Vickery, Julie Wang, Alexandra F. Santos   +10 more
wiley   +1 more source