Results 171 to 180 of about 449,551 (293)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Differential functional immune recall across homologous and heterologous COVID-19 vaccination regimens. [PDF]

Front Immunol
Che-Kamaruddin N, Johari J, Yahaya H, Zainal N, Nguyen HC, Hontz RD, Letizia AG, AbuBakar S.   +7 more
europepmc   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Nasal Nanoparticle Vaccine Induces a Cross-Strain T-Cell Immunity Against <i>Toxoplasma gondii</i>. [PDF]

Pharmaceutics
Lecouffe A, Bouillet T, Thiroux B, Degraeve A, Vreulx AC, Magnez R, Scuotto A, Barnier-Quer C, Betbeder D.   +8 more
europepmc   +1 more source

Immunogenicity and Protective Efficacy of the First Autogenous Aeromonas hydrophila Vaccine for Piaractus brachypomus

Journal of Fish Diseases, EarlyView.
ABSTRACT Aeromonas hydrophila is a major zoonotic bacterial pathogen responsible for haemorrhagic septicemia, substantial economic losses in aquaculture and increasing antimicrobial resistance among field isolates. It is also one of the main bacterial species associated with mortality outbreaks in pirapitinga, Piaractus brachypomus, culture in the ...
Layana Aparecida Batista Pereira, Juliana do Nascimento Ferreira, Laine Patricia Costa dos Santos, Larissa Andréia Ferreira Sampaio, Igor Bartolomeu Alves de Barros, Elizabeth Gusmão Affonso, Jefferson Yunis‐Aguinaga, Gustavo da Silva Claudiano   +7 more
wiley   +1 more source

Trained Immunity in Host Defense: Mechanisms, Pathogen Interactions, and Therapeutic Potential. [PDF]

Pathogens
Siddiqui F, Datta A, Choubey S, Bhadra S, Siddiqui A, Sadawarte K.   +5 more
europepmc   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Long-term immunity and protection against SARS-CoV-2 XBB.1.5 following homologous and heterologous mRNA and MVA vaccination. [PDF]

Front Immunol
Pérez P, Esteso G, García-García I, Flores S, Sánchez-Corzo C, Noriega MA, Casasnovas JM, Esteban M, García-Arriaza J.   +8 more
europepmc   +1 more source

Light signaling controls chloroplast pyruvate metabolism through the STF1/2–PKP1 module in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, light‐responsive proteins switch on GmPKP1, which boosts chloroplast pyruvate production. This increases pigments, photosynthesis, seed oil, pod number, and yield, revealing a new way that light boosts crop productivity. ABSTRACT Light signaling coordinates plant development with metabolism, but the link between photoreceptors and ...
Faming Lin, Xiaoran Wang, Chenhao Zhao, Shaolong Yang, Jingnan Xu, Hongyi Su, Ruixiang Lei, Yilei Xu, Jike Xue, Ming Chang, Fanjiang Kong, Ran Wang   +11 more
wiley   +1 more source

A universally conserved OMV-YidR conjugate nanovaccine confers broad protection against hypervirulent and carbapenem-resistant <i>Klebsiella pneumoniae</i>. [PDF]

Emerg Microbes Infect
He S, Zhang Y, Song A, Fan C, Zhao F, Zhou W, Xie C, Guo C, Chen S, Chen Y.   +9 more
europepmc   +1 more source