Results 31 to 40 of about 2,138,040 (291)

Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans

Frontiers in Immunology, 2021
Diabetes-related cognitive dysfunction (DRCD) is a serious complication induced by diabetes. However, there are currently no specific remedies for DRCD. Here, we show that streptozotocin-induced DRCD can be prevented without causing side effects through ...
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Hiroyuki Inagawa, Hiroyuki Inagawa, Chie Kohchi, Chie Kohchi, Gen-Ichiro Soma, Gen-Ichiro Soma, Gen-Ichiro Soma   +11 more
doaj   +1 more source

Vascular Endothelial Cells and Innate Immunity.

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively participate in both innate and adaptive immune responses. We previously reported that, in comparison to macrophages, a prototypic innate immune cell type, ECs ...
Ying Shao, J. Saredy, William Y. Yang, Yu Sun, Yifan Lu, Fatma Saaoud, C. Drummer, Candice Johnson, Keman Xu, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +11 more
semanticscholar   +1 more source

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Nature Communications
Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane.
Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C. Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt   +13 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Cell Death and Disease
Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli, Rebecca L. Ambrose, Christopher M. Harpur, Maggie Lam, Christopher Hodges, Kristian T. Barry, Alison C. West, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate   +9 more
doaj   +1 more source

Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection

Microorganisms, 2021
The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UPR initiates transcriptional and post-transcriptional programs to resolve ER stress; or, if ER stress is severe or prolonged,
Manal H. Alshareef, Elizabeth L. Hartland, Kathleen McCaffrey   +2 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Innate immunity in rice [PDF]

Trends in Plant Science, 2011
Advances in studies of rice innate immunity have led to the identification and characterization of host sensors encoding receptor kinases that perceive conserved microbial signatures. Receptor kinases that carry the non-orginine-aspartate domain, are highly expanded in rice (Oryza sativa) compared with Arabidopsis (Arabidopsis thaliana).
Chen, Xuewei, Ronald, Pamela C
openaire   +4 more sources