Results 11 to 20 of about 3,965,028 (421)
Nature Communications, 2023 A gB/MF59 vaccine candidate for human cytomegalovirus (HCMV) provided partial protection in organ transplant patients. Here, the authors identify antibody responses in trial participants that target virally infected cells to control cell-to-cell spread ...
A. C. Gomes +10 more
doaj +1 more source
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
Nature Communications, 2022 Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a ...
Mariya Misheva +23 more
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Interaction between microbiota and immunity in health and disease
Cell Research, 2020 The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of
D. Zheng, T. Liwinski, E. Elinav
semanticscholar +1 more source
Comparison of antibody responses to SARS-CoV-2 variants in Australian children
Nature Communications, 2022 Despite a rise in COVID-19 cases among children, there is limited understanding of the antibody responses mounted, compared to in adults. In this work, authors compare seroconversion rates and antibody responses in unvaccinated Australian children across
Zheng Quan Toh +12 more
doaj +1 more source
The trinity of COVID-19: immunity, inflammation and intervention
Nature reviews. Immunology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and ...
M. Tay +4 more
semanticscholar +1 more source
Biomedicines, 2022 Thyroid hormones have immunomodulatory roles, but their effects on the transcriptome and epigenome of innate immune cell types remain unexplored. In this study, we investigate the effects of triiodothyronine (T3) on the transcriptome and methylome of ...
Rebecca Shepherd +3 more
doaj +1 more source
Nature Communications, 2022 Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires CD28 ...
Chun Jing Wang +14 more
doaj +1 more source
Nature Communications, 2022 Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated ...
Nekisa Zakeri +12 more
doaj +1 more source
Plant immunity: towards an integrated view of plant–pathogen interactions
Nature Reviews Genetics, 2010 Peter N Dodds, John P Rathjen
exaly +2 more sources
Mediators of Inflammation, 2023 Background. Neonatal sepsis is an extremely dangerous and fatal disease among neonates, and its timely diagnosis is critical to treatment. This research is aimed at evaluating the clinical significance of the lymphocyte-to-C-reactive protein ratio (LCR ...
Xiaojuan Li +8 more
doaj +1 more source