Results 21 to 30 of about 2,570,818 (334)
Biomedicines, 2022 Thyroid hormones have immunomodulatory roles, but their effects on the transcriptome and epigenome of innate immune cell types remain unexplored. In this study, we investigate the effects of triiodothyronine (T3) on the transcriptome and methylome of ...
Rebecca Shepherd +3 more
doaj +1 more source
Nature Communications, 2022 Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated ...
Nekisa Zakeri +12 more
doaj +1 more source
The evolution of resistance through costly acquired immunity [PDF]
, 2004 We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and ...
Boots M., Michael Boots, Roger G. Bowers
core +2 more sources
Infection-acquired versus vaccine-acquired immunity in an SIRWS model [PDF]
, 2017 Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity.
Campbell, Patricia T +4 more
core +2 more sources
'Towards a Conceptual Framework for Innate Immunity' [PDF]
, 2005 Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
core +3 more sources
Mediators of Inflammation, 2023 Background. Neonatal sepsis is an extremely dangerous and fatal disease among neonates, and its timely diagnosis is critical to treatment. This research is aimed at evaluating the clinical significance of the lymphocyte-to-C-reactive protein ratio (LCR ...
Xiaojuan Li +8 more
doaj +1 more source
Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children
Nature Communications, 2021 Childhood infection with SARS CoV2 is associated with a milder course of infection but the immunopathogenesis of this remains unclear. Here the authors explore immunological differences in the innate immune system during acute and convalescent SARS CoV2 ...
Melanie R. Neeland +11 more
doaj +1 more source
Immune privilege or privileged immunity? [PDF]
Mucosal Immunology, 2008 Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of peripheral tolerance.
Forrester, J.V. +3 more
openaire +4 more sources
Nature Communications, 2022 The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of SARS-CoV-2 specific T cell responses could prognosticate the risk of possible SARS ...
Martin J. Scurr +11 more
doaj +1 more source
BMJ Open, 2022 Introduction Maternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs of sepsis and can result in delays in recognition and treatment.
Daniel White +27 more
doaj +1 more source