Results 51 to 60 of about 1,564,380 (249)

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

BMC Infectious Diseases, 2021
Background Talaromyces marneffei (TM) bloodstream infection is common in Acquired Immunodeficiency Syndrome (AIDS) patients with extreme immunodeficiency in Southeast Asia and South China, however, clinical case study on TM bloodstream infection is ...
Jianjun Sun, Weiwei Sun, Yang Tang, Renfang Zhang, Li Liu, Yinzhong Shen, Jiangrong Wang, Jun Chen, Tangkai Qi, Zhenyan Wang, Wei Song, Yixiao Lin, Shuibao Xu, Hongzhou Lu   +13 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis

Scientific Reports, 2017
Pathogen-associated biliary fibrosis (PABF) is a type of liver fibrosis characterized by injuries of cholangiocytes and extra cellular matrix (ECM) deposition around bile ducts caused by various bacteria, fungi, virus and parasites.
Chao Yan, Bo Li, Fang Fan, Ying Du, Rui Ma, Xiao-Dan Cheng, Xiang-Yang Li, Bo Zhang, Qian Yu, Yu-Gang Wang, Ren-Xian Tang, Kui-Yang Zheng   +11 more
doaj   +1 more source

The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease

Scientific Reports, 2021
To understand the contribution of mononuclear phagocytes (MNP), which include monocyte-derived intestinal macrophages, to the pathogenesis of inflammatory bowel disease (IBD), it is necessary to identify functionally-different MNP populations.
Pamela B. Wright, Elizabeth McDonald, Alberto Bravo-Blas, Hannah M. Baer, Anna Heawood, Calum C. Bain, Allan M. Mowat, Slater L. Clay, Elaine V. Robertson, Fraser Morton, Jagtar Singh Nijjar, Umer Z. Ijaz, Simon W. F. Milling, Daniel R. Gaya   +13 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy [PDF]

, 2021
Pottayil G. Sasikumar, Naremaddepalli S. Sudarshan, Srinivas Adurthi, Raghuveer Ramachandra, Dodderi S. Samiulla, Anirudha Lakshminarasimhan, Anuradha Ramanathan, T. Chandrasekhar, Amit A. Dhudashiya, Sumalatha Rani Talapati, Nagesh Gowda, Sreenivasulareddy Palakolanu, Jiju Mani, Bandi Srinivasrao, David Joseph, Nigam Kumar, Rashmi Nair, Hanudatta S. Atreya, Nagaraj Gowda, Murali Ramachandra   +19 more
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study

BMC Medical Genomics
Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions.
Mingcan Tang, William Haese-Hill, Fraser Morton, Carl Goodyear, Duncan Porter, Stefan Siebert, Thomas D. Otto   +6 more
doaj   +1 more source

Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
Background. The myeloid enzyme 12/15-lipoxygenase (LOX), which generates bioactive oxidized lipids, has been implicated in numerous inflammatory diseases, with several studies demonstrating an improvement in pathology in mice lacking the enzyme. However,
Sarah N. Lauder, Victoria J Tyrrell, Keith Allen-Redpath, Maceler Aldrovandi, David Gray, Peter Collins, Simon A Jones, Philip R Taylor, Valerie O'Donnell   +8 more
doaj   +1 more source