Results 51 to 60 of about 3,965,028 (421)

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Science, 2020
Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al.
P. Arunachalam, F. Wimmers, C. K. Mok, Ranawaka A.P.M Perera, Madeleine K. D. Scott, T. Hagan, Natalia Sigal, Yupeng Feng, Laurel Bristow, Owen Tak-Yin Tsang, D. Wagh, J. Coller, K. Pellegrini, Dmitri Kazmin, Ghina Alaaeddine, W. Leung, J. Chan, T. Chik, Chris Yau-Chung Choi, C. Huerta, Michele Paine McCullough, Huibin Lv, E. Anderson, Srilatha Edupuganti, Amit A. Upadhyay, S. Bosinger, H. Maecker, P. Khatri, N. Rouphael, M. Peiris, B. Pulendran   +30 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Hepatitis B: Model Systems and Therapeutic Approaches

Journal of Immunology Research
Hepatitis B virus (HBV) infection is a major global health issue and ranks among the top causes of liver cirrhosis and hepatocellular carcinoma. Although current antiviral medications, including nucleot(s)ide analogs and interferons, could inhibit the ...
Xiaoxiao Yu, Yating Gao, Xin Zhang, Longshan Ji, Miao Fang, Man Li, Yueqiu Gao   +6 more
doaj   +1 more source

Modeling the long term dynamics of pre-vaccination pertussis

, 2012
The dynamics of strongly immunizing childhood infections is still not well understood. Although reports of successful modeling of several incidence data records can be found in the literature, the key determinants of the observed temporal patterns have ...
Ana Nunes, Anderson R. A., Centers for Disease Control and Prevention, Ganna Rozhnova, van Kampen N. G.   +4 more
core   +1 more source

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways

Arthritis Research & Therapy, 2023
Objectives Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA).
Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes, Gerard Graham   +4 more
doaj   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires [PDF]

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV).
arxiv   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS.
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang   +7 more
doaj   +1 more source