Results 51 to 60 of about 4,133,580 (421)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Hepatitis B: Model Systems and Therapeutic Approaches

Journal of Immunology Research
Hepatitis B virus (HBV) infection is a major global health issue and ranks among the top causes of liver cirrhosis and hepatocellular carcinoma. Although current antiviral medications, including nucleot(s)ide analogs and interferons, could inhibit the ...
Xiaoxiao Yu, Yating Gao, Xin Zhang, Longshan Ji, Miao Fang, Man Li, Yueqiu Gao   +6 more
doaj   +1 more source

Identification of a MicroRNA‐E3 Ubiquitin Ligase Regulatory Network for Hepatocyte Death in Alcohol‐Associated Hepatitis

Hepatology Communications, 2021
We aimed to identify a microRNA (miRNA)‐E3 ubiquitin ligase regulatory network for protein substrates enriched in cell death pathways and investigate the underlying molecular mechanisms in alcohol‐associated hepatitis (AH).
Xiude Fan, Jianguo Wu, Kyle L. Poulsen, Adam Kim, Xiaoqin Wu, Emily Huang, Tatsunori Miyata, Carlos Sanz‐Garcia, Laura E. Nagy   +8 more
doaj   +1 more source

Modeling the long term dynamics of pre-vaccination pertussis

, 2012
The dynamics of strongly immunizing childhood infections is still not well understood. Although reports of successful modeling of several incidence data records can be found in the literature, the key determinants of the observed temporal patterns have ...
Ana Nunes, Anderson R. A., Centers for Disease Control and Prevention, Ganna Rozhnova, van Kampen N. G.   +4 more
core   +1 more source

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires [PDF]

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV).
arxiv   +1 more source

Tumor-Associated Macrophages in Tumor Immunity

Frontiers in Immunology, 2020
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Yueyun Pan, Yinda Yu, Xiaojian Wang, Ting Zhang   +3 more
semanticscholar   +1 more source

Ferroptosis in infection, inflammation, and immunity

Journal of Experimental Medicine, 2021
In this review, the authors focus on ferroptosis in innate and adaptive immunity. They also discuss and highlight the impact of ferroptotic death in infection, inflammation, and immune diseases.
Xin Chen, R. Kang, G. Kroemer, D. Tang
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source