Results 51 to 60 of about 2,498,524 (354)

Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways

Arthritis Research & Therapy, 2023
Objectives Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA).
Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes, Gerard Graham   +4 more
doaj   +1 more source

Vitamin D and immunity [PDF]

, 2014
Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,
Geldenhuys, Sian, Gorman, Shelley, Hart, Prue, Lucas, Robyn   +3 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection

mBio
There are no licensed vaccines for human cytomegalovirus (HCMV), and current antiviral drugs that target viral proteins are toxic and prone to resistance.
Pragati S. Amratia, Lauren E. Kerr-Jones, Lucy Chapman, Morgan Marsden, Mathew Clement, Richard J. Stanton, Ian R. Humphreys   +6 more
doaj   +1 more source

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility

Frontiers in Immunology, 2018
T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in ...
Christopher J. Holland, Christopher J. Holland, Bruce J. MacLachlan, Valentina Bianchi, Valentina Bianchi, Sophie J. Hesketh, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre J. Rizkallah, Stephen Wells, David K. Cole, David K. Cole   +16 more
doaj   +1 more source

STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS.
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang   +7 more
doaj   +1 more source

Section 1983: Absolute Immunity for Pretrial Police Testimony [PDF]

, 1987
This Note discusses the development of the Supreme Court\u27s approach to section 1983 immunity for trial witnesses. Central to this discussion is an overview of the history of common-law immunities for government officials, the history and purpose of ...
Kaufman, Jack
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Foreign Sovereign Immunity and Domestic Officer Suits [PDF]

, 2010
Under international law, official-capacity suits brought against a foreign state’s officers are treated as suits against the state itself and thus as subject to the state’s immunity, even in suits alleging human rights abuses.
Bradley, Curtis A., Goldsmith, Jack L.
core   +2 more sources

Beyond the ‘other’ as constitutive outside: : The politics of immunity in Roberto Esposito and Niklas Luhmann [PDF]

, 2016
This article re-conceptualises the ‘constitutive outside’ through Roberto Esposito’s theory of immunity to detach it from Laclau and Mouffe’s political antagonism.
Richter, Hannah
core   +2 more sources