Results 61 to 70 of about 2,570,818 (334)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction
Frontiers in Immunology, 2018 NK cells have potent antitumor capacity. They are enriched in the human liver, with a large subset specialized for tissue-residence. The potential for liver-resident versus liver-infiltrating NK cells to populate, and exert antitumor functions in, human ...
Nicholas J. W. Easom +11 more
doaj +1 more source
A Test of Sovereignty: Franchise Tax Board of the State of California v. Gilbert P. Hyatt [PDF]
, 2019 In Franchise Tax Board of California v. Hyatt, the Supreme Court considers whether to overrule Nevada v. Hall, a 1979 Supreme Court decision. Hall permitted a State to be haled into the court of another State without its consent.
Dill, Timothy
core +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
Nature Communications, 2019 Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can
Sharyn Thomas +16 more
doaj +1 more source
BMC Infectious Diseases, 2021 Background Talaromyces marneffei (TM) bloodstream infection is common in Acquired Immunodeficiency Syndrome (AIDS) patients with extreme immunodeficiency in Southeast Asia and South China, however, clinical case study on TM bloodstream infection is ...
Jianjun Sun +13 more
doaj +1 more source
Clinical Infectious Diseases, 2014 Pregnant women, neonates, and infants are at higher risk for severe infections due to vaccine‐preventable diseases. Very young infants rarely respond well to vaccination due to poor immunogenicity and interference from maternal antibody. Maternal immunization protects the mother and fetus from disease and protects the infant through transplacental ...
Helen Y. Chu, Janet A. Englund
openaire +5 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source