Results 81 to 90 of about 3,965,028 (421)
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
Nature Communications, 2019 Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can
Sharyn Thomas +16 more
doaj +1 more source
Frontiers in Immunology, 2018 T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in ...
Christopher J. Holland +16 more
doaj +1 more source
Microbiome, 2023 Background Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis is altered in high-fat diet (HFD)-induced cognitive impairment and is closely associated with ...
Wei Pan +15 more
doaj +1 more source
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System [PDF]
, 2006 Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The
arxiv +1 more source
The Prosecutor\u27s Obligation to Grant Defense Witness Immunity [PDF]
, 1988 The author enumerates the three most common situations in which the courts have required the prosecutor to offer immunity to defense witnesses: (1) to safeguard the defendant\u27s right to essential exculpatory testimony; (2) where the use of the ...
Gershman, Bennett L.
core +1 more source
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Canonical immunity and genericity [PDF]
arXiv, 2017 Whereas the usual notions of immunity -- e.g., immunity, hyperimmunity, etc. -- are associated with Cohen genericity, canonical immunity, as introduced by Beros, Khan and Kjos-Hanssen, is associated instead with Mathias genericity. Specifically, every Mathias generic is canonically immune and no Cohen 2-generic computes a canonically immune set.
arxiv
SIRS epidemics with individual heterogeneity of immunity waning [PDF]
arXiv, 2023 We analyse an extended SIRS epidemic model in which immunity at the individual level wanes gradually at exponential rate, but where the waning rate may differ between individuals, for instance as an effect of differences in immune systems. The model also includes vaccination schemes aimed to reach and maintain herd immunity.
arxiv
IL-6 in inflammation, immunity, and disease.
Cold Spring Harbor Perspectives in Biology, 2014 Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.
Toshio Tanaka, M. Narazaki, T. Kishimoto
semanticscholar +1 more source