Journal of Intelligent Medicine, Volume 1, Issue 1, Page 63-90, December 2024.Abstract Colorectal cancer (CRC) ranks as the world's second most prevalent cancer and third in mortality. Detection and diagnosis are crucial in research and clinical settings. While colonoscopy and computed tomographic colonography are widely used for identifying organic lesions, positron emission tomography (PET) and single‐photon emission computed ...
Surui Chen +5 more
wiley +1 more source
Evaluation of a novel human IgG1 anti-claudin3 antibody that specifically recognizes its aberrantly localized antigen in ovarian cancer cells and that is suitable for selective drug delivery [PDF]
, 2015 Membrane protein claudin3 has been recently suggested as a marker for biologically aggressive tumors and a possible target for the therapeutic delivery of active anti-cancer compounds.
Bandiera, Elisabetta +15 more
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Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Nature Communications, 2019 Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Anna Galstyan +20 more
doaj +1 more source
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids [PDF]
, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Brun Cubero, Omar +3 more
core +2 more sources
Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors. [PDF]
, 2016 Background IMGN901 is a CD56-targeting antibody-drug conjugate designed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and preliminary activity of IMGN901 in ...
A Ballantyne +34 more
core +3 more sources
Toxins, 2019 Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán +4 more
doaj +1 more source
, 2011 International audienceFor the first time, α-emitter radioisotope (213)Bi has been incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide.
Boitrel, Bernard +9 more
core +3 more sources
Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy [PDF]
, 2016 Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells.
Boyle, RW +6 more
core +3 more sources
Gene expression signature in mouse thyroid tissue after 131I and 211At exposure [PDF]
, 2015 BACKGROUND: (131)I and (211)At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile variations, assess the impact on cellular activity, and
Britta Langen +6 more
core +1 more source
Investigation into metastatic processes and the therapeutic effects of gemcitabine on human pancreatic cancer using an orthotopic SUIT-2 pancreatic cancer mouse model. [PDF]
, 2019 学位記番号 ...
Higuchi, Tamami +2 more
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